超声造影剂灌注曲线斜率与流速相关性的初步研究  

Correlation between slope rate of flash-replenishment curve of ultrasonic contrast imaging and the flow velocity in the model of microcirculatory dynamics:initial exploration

作　　者：路晶[1] 周翔[1] 谢明星[1] 王新房[1] 吕清[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院超声影像科湖北省分子影像重点实验室,湖北武汉430022

出　　处：《中国医学影像技术》2007年第11期1717-1720,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨超声Flash-replenishment成像技术中超声造影剂灌注曲线斜率与流速的相关性。方法采用自制动力泵-超滤纤维系统模拟器官微循环血流动力学,建立微循环血流模型。连续输注20ml造影剂SonoVue(1∶3稀释),应用FR成像技术,分别测定微循环流速为0.25mm/s、0.5mm/s、1mm/s、2mm/s、4mm/s、8mm/s时造影剂的再灌注曲线斜率β,对β值与实际流速进行相关性分析。结果微循环流速为2～8mm/s时β值与实际流速相关性良好,r=0.97;微循环流速为0.25～1mm/s,二者相关性较差,r=0.44。结论微循环流速低于1mm/s以下时,造影剂再灌注曲线的β值与实际流速相关性差,故低流速状态下造影剂的灌注定量方法有待进一步研究。Objective To investigate the correlation between the slope of flash-replenishment curve of ultrasonic contrast imaging and the flow velocity in the model of microcirculatory dynamics.Methods An in-vitro model of microcirculatory dynamics was built up using pump-ultrafiltration fiber system made by ourselves.The values of β（the slope rate of time-intensity curve of contrast）derived from the flash-replenishment imaging technique were measured at the flow velocity of 0.25 mm/s,0.5 mm/s,1 mm/s,2 mm/s,4 mm/s,8 mm/s,respectively.The correlation between the values of β and the different flow velocities was analyzed.Results The value of β and flow velocity correlated well within the range of 2 mm/s-8 mm/s（r=0.97）.On the other hand,the correlation of β and flow velocity from 0.25 mm/s to 1 mm/s was poor（r=0.44）.Conclusion It is a complex problem that the correlation between the value of β and microcirculation flow velocity is poor when the velocity is slower than 1 mm/s.The perfusion quantification for the very low flow velocity demands further research.

关 键 词：超声造影剂 连续灌注 Flash-replenishment 

分 类 号：R445.1[医药卫生—影像医学与核医学]