2型糖尿病家系与尾加压素2基因多态性  

Relationship between polymorphism of urotensin Ⅱ gene and type 2 diabetes in pedigrees

作　　者：吴雪霁[1] 秦蕾[1] 周金意[1] 成金罗[2] 沈默宇[2] 王劲松[3] 周玲[1] 

机构地区：[1]南京医科大学流行病与卫生统计学系,210029 [2]江苏省常州市第二人民医院内分泌科 [3]扬州大学医学院流行病学教研室

出　　处：《中华医学遗传学杂志》2007年第6期656-659,共4页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金（30371241）

摘　　要：目的探讨我国常州地区汉族家系2型糖尿病与尾加压素2（urotensinⅡ,UT-Ⅱ）基因rs228648多态性位点的关系。方法采用家系内外对照的病例对照研究,并设置无家族史的普通病例组,应用聚合酶链反应-限制性片段长度多态性技术,对rs228648（G/A）多态性进行基因分型。结果家系中携带AG和AA基因型者患病风险分别为GG型的1.98（95%可信区间=1.19～3.29）和2.46（95%可信区间=1.39～4.34）倍,家系病例组A等位基因频率高于内对照组及普通病例组（P=0.01）。内对照组A等位基因频率高于外对照组（P=0.001）。内对照组携带AG基因型者的胰岛素抵抗指数、胰岛素敏感指数以及胰岛初期分泌功能指数均高于GG基因型者（P〈0.05）。结论rs228648多态性位点变异可能是2型糖尿病的危险因素之一,家系人群该基因变异与其胰岛功能间存在关联。Objective To investigate the association between a polymorphism （rs228648） of urotensin Ⅱ （UTⅡ） gene and type 2 diabetes in pedigrees. Methods Patients and controls with/without familial history were enrolled in the same place. Results Carriers with AG or AA genotype from pedigrees had higher disease risk than those with GG genotype（ OR = 1.98, 95% CI： 1.19-3.29, OR = 2.46,95% CI： 1.39-4.34）, the frequency of A allele was higher in the patients from pedigrees than inner controls and patients who had no familial history（ P = 0.01 ）. The frequency of A allele was higher in the inner controls than outer ones（ P = 0.001）. The insulin resistance index, insulin sensitivity index and pancreatic secretion index of inner controls with AG genotype were higher than those with GG genotype（All P 〈 0.05）. Conclusion This polymorphism of UT-Ⅱ gene might be a risk to type 2 diabetes, the insulin function of people from pedigrees is associated with the mutation.

关 键 词：尾加压素2基因 2型糖尿病 遗传多态性 

分 类 号：R686[医药卫生—骨科学]