凉血通瘀口服液治疗出血性中风病急性期瘀热阻窍证的临床研究  

Clinic study of Liangxue Tongyu oral solution(凉血通瘀口服液) in treatment of patients with hemorrhagic stroke at acute stage and traditional Chinese medical syndrome of stagnant heat and obstruction of orifices(瘀热阻窍证)

作　　者：金妙文[1] 周仲瑛[1] 樊蓥[1] 吴勉华[1] 周学平[1] 王志英[1] 汪红[1] 

机构地区：[1]南京中医药大学,江苏南京210029

出　　处：《中国中西医结合急救杂志》2007年第6期323-326,共4页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：国家"973"重点发展计划基金资助项目(2006CB504807)

摘　　要：目的:观察凉血通瘀口服液对出血性中风病急性期的治疗作用。方法:应用凉血通瘀口服液治疗32例出血性中风病急性期瘀热阻窍证患者,以应用西医内科综合疗法治疗的32例患者作为对照。观察患者主要症状、体征、脑血肿、脑水肿、神经系统体征总积分以及血液流变学指标的变化。结果:应用凉血通瘀口服液的治疗组临床愈显率为62.5%,总有效率为96.9%,均明显优于单纯西药对照组21.9%、81.2%(P<0.01和P<0.05)。治疗组治疗后7 d意识障碍恢复率明显高于对照组(90.9%比58.3%,P<0.05);两组治疗后脑出血量均较治疗前显著减少〔治疗组(2.83±4.19)m l比(19.22±13.39)m l,对照组(4.46±4.01)m l比(19.16±9.82)m l,P均<0.01〕,但治疗后两组比较差异无统计学意义;治疗组治疗后脑水肿分级改善程度(A级19例比11例)、神经系统体征总积分减少〔(5.69±5.10)分比(10.56±8.51)分〕,以及血液流变学指标改善程度均明显好于对照组(P<0.05或P<0.01)。结论:凉血通瘀口服液具有促进脑内血肿的吸收、减轻继发性脑水肿、促进意识恢复、减轻患者神经功能损伤等综合作用,从而提高临床疗效。Objective： To study the therapeutic effect of Liangxue Tongyu oral solution（凉血通瘀口服液） in treatment of patients with hemorrhagic stroke at acute stage.Methods： Thirty two cases with hemorrhagic stroke at acute stage and traditional Chinese medical（TCM） syndrome of stagnant heat and obstruction of orifices（瘀热阻窍证） were treated with Liangxue Tongyu solution（treated group）,and thirty two cases of the same disease and syndrome were treated with conventional western medicine（control group）.The changes of main clinical symptoms,signs,the volume of intracerebral hematoma,the cerebral edema score,the nervous system physical sign assessment score and the indexes of hemorheology were observed. Results： In treated group,the total efficiency was 96.9% and the significant efficiency was 62.5%.In control group,the total efficiency was 81.2% and the significant efficiency was 21.9%,There were significant differences between the two groups（P〈0.05 and P〈0.01）.In seven days,the recovery rate of the conscious disturbance was 90.9% in treated group and 58.3% in control group（P〈0.05）. The volumes of intracerebral hematoma were markedly decreased in both groups after treatment compared with those before treatment（（2.83±4.19） ml vs.（19.22±13.39） ml in treated group and（4.46±4.01） ml vs.（19.16±9.82） ml in control group,both P〈0.01）,there was no significant difference between the two groups after treatment（P〉0.05）.After treatment,according to A scale cerebral edema assessment score,the improvement of cerebral edema was 19 cases in treated group and 11 cases in control group,according to the nervous system physical sign assessment score,the score was lower in treated group（5.69±5.10） score than that in control group（10.56±8.51） score and the indexes of hemorheology of treated group were superior to those in control group（P〈0.05 or P〈0.01）.Conclusion： Liangxue Tongyu oral solution possesses significant effects on promoting absor

关 键 词：中风 出血性 瘀热阻窍证 凉血通瘀口服液 临床疗效 

分 类 号：R255.2[医药卫生—中医内科学]