新型抗生素89-07对大鼠肾毒性的评价  

Nephrotoxicity evaluation study on antibiotic 89 07, a new antibiotic, in rats

作　　者：林赴田[1] 于锋[1] 曹忆瑾 赵敏[2,3] 范瑾[2,3] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所 [2]江苏省微生物研究所 [3]上海医科大学华山医院抗生素研究所

出　　处：《中国抗生素杂志》1997年第3期201-205,共5页Chinese Journal of Antibiotics

基　　金：国家新药基金

摘　　要：抗生素８９－０７是庆大霉素新型的衍生物，给大鼠肌注３０、９０和１２０ｍｇ／ｋｇ，每日１次，为期７ｄ或２１ｄ，并与庆大霉素（ＧＭ）等剂量进行肾毒性比较，结果表明，ＧＭ１２０ｍｇ／ｋｇ组引起大鼠肾功能的损害包括尿蛋白、尿糖、尿酶的活性，一般毒性症状和体重增长受抑制比抗生素８９－０７等剂量严重。病理组织学检查证明，ＧＭ和抗生素８９－０７的９０和１２０ｍｇ／ｋｇ剂量主要是肾近曲小管上皮细胞损伤，抗生素８９－０７仅有轻度近曲小管上皮细胞退行性改变，而ＧＭ除细胞退行变性外，有部分细胞坏死，肾小管内有蛋白管型和细胞管型。The nephrotoxic potentials of the new gentamicin derivative, antibiotic 89 07 and gentamicin were compared in Wistar strain rats at intramuscular daily doses of 30, 90 and 120mg/kg for 7 or 21 days, respectively. Result showed that, in renal founction test, gentamicin group tended to produce more abnormal changes than antibiotic 89 07 group with respect to protein, sugar, lysozyme excretion in the urine, toxic signs and suppression of weight gain at 120mg/kg dose. Histopathologically, main lesions were found in the proximal convoluted tubular eptithelium in both antibiotic 89 07 and gentamicin groups. A finding observed with antibiot 89 07 groups at 90 and 120mg/kg doses were very slight degeneration without necrosis, whereas that found with gentamicin group at same doses were partial necrosis and renal tubule in protein and cell casts.

关 键 词：抗生素89-07 庆大霉素 肾毒性 氨基糖苷 新药 

分 类 号：R978.12[医药卫生—药品] R992[医药卫生—药学]