美罗培南对严重感染患者肾脏功能的影响  

Effect of meropenem on renal function of patients with severe infection

作　　者：江秀慧 颜琳 侯立朝[3] 熊利泽[3] 王强[3] 霍婷婷[3] 胡文能[3] 陈绍洋[3] 熊东方[3] 陈敏[3] 白晓光[3] 

机构地区：[1]唐河县红十字会医院内科,河南唐河473400 [2]西安杨凌示范区医院麻醉科,陕西西安712100 [3]第四军医大学西京医院麻醉科,陕西西安710033

出　　处：《第四军医大学学报》2007年第23期2185-2187,共3页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金(30170361;30471675)

摘　　要：目的:回顾性分析美罗培南用于抗感染治疗时对肾脏功能的影响,为临床合理用药提供参考.方法:按照病情相近的原则选择1998年以来在我科ICU接受治疗的严重肺部感染患者35例,按照患者使用美罗培南时的剂量不同分为A,B,C三组.在抗感染治疗前、后记录患者的尿量、血尿素氮和肌酐、尿白蛋白和β2微球蛋白定量.结果:给予美罗培南等综合治疗前,所有患者BUN,CRE,U-ALB和Uβ2-MG定量均高于正常范围,组间比较其差别无统计学意义(P>0.05).给予抗感染等综合治疗后,所有患者BUN,CRE,U-ALB和Uβ2-MG均有所下降(P<0.01),其中U-ALB和Uβ2-MG仍高于正常;三组患者尿量,BUN,CRE,U-ALB和Uβ2-MG的变化组间比较均无统计学意义(P>0.05).结论:美罗培南用于治疗严重感染时不影响患者肾脏功能的恢复,感染的控制是肾脏功能恢复的基础.AIM： To retrospectively study the effect of meropenem on the renal function of the patients with severe infection. METHODS： Thirty-five patients with septic shock who had similarity in their condition and were admitted into ICU of our department since 1998, were enrolled in this study. And according to the difference in the administration dose of meropenem, they were divided into three groups： Group A, Group B and Group C. The urine output, blood urea nitrogen, blood creatinine, urine albumin and urine β2 microglobulin were determined and recorded for each patient. RESULTS： Before meropenem and other combined therapy were given, blood urea nitrogen, blood creatinine, urine albumin and urine β2 microglobulin output in all patients were abnormally higher, with no statistical difference among the three groups （P 〉 0. 05 ）. After the above combined therapy, blood urea nitrogen, blood creatinine, urine albumin and urine β2 microglobulin output in all patients declined significantly （P 〈 0.01 ） , among which, urine albumin and urine β2 microglobulin output were still abnormal in all patients, and the changes of urine output, blood urea nitrogen, blood creatinine, urine albumin and urineβ2 microglobulin output had no statistically significant difference among the three groups （ P 〉 0.05 ）. CONCLUSION： Meropenem does not influence the restoration of the renal function in the patients with severe infection, and the control of infection could play a foundation for the recovery of the renal function.

关 键 词：感染 美罗培南 肾功能 

分 类 号：R515[医药卫生—内科学]