Preparation and Degradation Characteristics of Poly(d,1-laetide) Composite Films  

作　　者：陈蕾 李世普 

机构地区：[1]Biomedical Materials and Engineering Research Center,Wuhan University of Technology

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2007年第4期691-694,共4页武汉理工大学学报（材料科学英文版）

基　　金：Funded by"973"Project(No.2005CB623905)

摘　　要：PDLLA/CHI/β-TCP/NGF composite films were prepared by a solvent evaporation method. The degradation characteristics of the poly （d, l-lactide） composite films were studied in vitro and in vivo. The acidity produced by poly （d, l-lactide） materials was not obvious. Adding chitosan and β-TCP can relieve the acidity problem and improve strength performance of films. The NGF has influences on the degradation characteristics of films. It is verified that PDLLA/CHI/β-TCP/NGF composite films prepared by solvent evaporation method have excellent degradation characteristics. It can be used as a perfect biomaterial for repairing nerve injuries.PDLLA/CHI/β-TCP/NGF composite films were prepared by a solvent evaporation method. The degradation characteristics of the poly （d, l-lactide） composite films were studied in vitro and in vivo. The acidity produced by poly （d, l-lactide） materials was not obvious. Adding chitosan and β-TCP can relieve the acidity problem and improve strength performance of films. The NGF has influences on the degradation characteristics of films. It is verified that PDLLA/CHI/β-TCP/NGF composite films prepared by solvent evaporation method have excellent degradation characteristics. It can be used as a perfect biomaterial for repairing nerve injuries.

关 键 词：poly （d  l-lactic acid） （PDLLA） chitosan （CHI） Β-TCP nerve growth factor （NGF） degradation characteristics 

分 类 号：TB383.2[一般工业技术—材料科学与工程]