^(131)Ⅰ ^(132)Ⅰ致大鼠甲状腺损伤远期效应的形态计量学研究(腺体水平研究)  

Morphometric study on late effect of 131 Ⅰ、 132 Ⅰ on rat thyroid gland(Study on gland level)

作　　者：曹珍山[1] 涂开成[1] 樊飞跃[1] 谢国良 杨素霞[1] 李煜[1] 刘国廉[1] 叶常青[1] 

机构地区：[1]北京放射医学研究所

出　　处：《中国辐射卫生》1997年第2期65-68,共4页Chinese Journal of Radiological Health

摘　　要：应用图像分析技术和形态计量学方法，测量了１３１Ⅰ、１３２Ⅰ致大鼠甲状腺损伤后（２０个月后）甲状腺三维体视学参数的变化。结果表明，各剂量组胶体和滤泡的体积密度及表面积密度均明显小于０剂量组，且随着吸收剂量的增大逐渐减小（Ｐ＜０．０１）；间质的体积密度则随着剂量的增大而明显增大（Ｐ＜０．０１）；各剂量组胶体和滤泡的比表面均明显大于０剂量组的值（Ｐ＜０．０１），说明胶体或滤泡的体积变小；由体积密度和表面积密度与吸收剂量的回归方程式计算的半增或半减剂量Ｄ５０，而推算出１３２Ⅰ相当于１３１Ⅰ的相对生物效应（ＲＢＥ）为１０～２５。即在相同的剂量照射条件下，１３２Ⅰ对甲状腺的损伤程度要比１３１Ⅰ大１０～２５倍。Changes are reported here in three dimensional stereologic parameters of rat thyroid glands at 20 months after injury induced by 131 Ⅰ、 132 Ⅰ with image analysis and morphometric methods.The results showed that colloid and follicular volume density and surface area density of various dosage groups were all significautly smaller than those of the control (0 dose) group,and were dose-dependent(P<0 01).However the volume density of interstitial tissue was negatively dose-dependent(P<0 01).The colloid and follicular specific surface area of various dosage groups were all significantly larger than those of the control group(P<0 01),indicating colloid and follicular volumes were decreased.It is confirmed that by the semi-increase or semi-reduction dose D 50 calculated from the regression equation of volume density,surface area density,and absorbed dose that the relative biological effectiveness(RBE) of 132 Ⅰ was 10～25-fold of 131 Ⅰ,i.e.,with same irradiation dose,the extent of injury induced by 132 Ⅰ would be 10～25 times larger than that by 131 Ⅰ.

关 键 词：形态计量学 碘131 碘132 放射性碘 甲状腺损伤 

分 类 号：R816.6[医药卫生—放射医学]