适于脑功能活动检测的便携式近红外光谱仪的研制  

A Portable Instrument for Brain Activity Detection Based on Near-infrared Spectroscopy

作　　者：郑毅[1] 骆清铭[1] 刘谦[1] 李婷[1] 张中兴[1] 龚辉[1] 

机构地区：[1]华中科技大学生物医学光子学教育部重点实验室武汉光电国家实验室(筹)生物医学光子学研究部,武汉430074

出　　处：《中国生物医学工程学报》2007年第6期898-902,共5页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金项目(30070261;60478016)。

摘　　要：研制一种新型的可用于研究脑功能活动的16通道便携式近红外光谱仪(NIRS)。系统探头柔软性强,与待测部位有良好贴附性,可探测面积为4.4cm×15cm的前额叶区域。选用集成化探测器、光源及其驱动芯片和基于USB接口的掌上型数据采集卡,使整机重量控制在1kg以内。用Visual C++6.0平台开发配套软件,系统的时间分辨率可通过软件设置,最高达100ms。监测Valsalva手法诱导脑血流调节过程的结果表明,系统能够实时测量人脑前额叶皮层血氧和血容量变化情况,从而反映出待测区域功能活动的强弱,为研究大脑认知神经活动提供了条件。A multi-channel（16）,portable brain function instrument based on near-infrared spectroscopy（NIRS） was presented.The probe,covering the area of 4.4cm×15cm of prefrontal cortex,is flexible and easy to attach to the tissue of interest.By employing integrated detector,light source,LED driver and palmtop data acquisition board（DAB） with USB port,the net weight of whole system was limited to 1kg.The software was developed by Visual C＋＋6.0.The maximum temporal resolution was up to 100ms which can be set by program.Valsalva maneuver was used to induce the regulation of blood pressure.The results showed that the system could monitor the changes in the amount of hemoglobin and blood volume,which could be regarded as the reflection of the functional activity.The system is promising in for the research on some cognitive neural activities.

关 键 词：近红外光谱术 时间分辨率 脑功能 前额叶皮层 

分 类 号：R318[医药卫生—生物医学工程]