实验性股骨头缺血坏死的药物治疗  

DRUG TREATMENT OF EXPERIMENTAL FEMORAL HEAD NECROSIS

作　　者：张念非 李子荣 杨连发 岳德波 郑振辉 

出　　处：《中日友好医院学报》1997年第2期109-112,共4页Journal of China-Japan Friendship Hospital

基　　金：卫生部科研基金

摘　　要：目的：探讨用保守方法治疗实验性股骨头坏死。方法：给予类固醇激素，诱导出兔股骨头坏死动物模型，同时使用大蒜素和川芎嗪治疗，然后采用放射性微球技术测量其股骨头血流量。结果：本方法可增加模型动物股骨头血流量，其增加幅度与对照组相比有显著差异（Ｐ＜００５）。结论：川芎嗪和大蒜素与类固醇激素同时应用可预防股骨头坏死的发生，并对已发生的早期股骨头坏死有一定的治疗作用。Objective:To study conservative treatment of experimental femoral head necrosis.Method:On the basis of successfuly induced rabbit models of femoral head necrosis,using Lingustrazine and Garlicin to treat the rabbits,and then,bone blood flow of femoral head was measured with radioactive microsphere technique.Result: Lingustrazine and Garlicin given at the same time immediately or 4 weeks after establishment the model,could signifignantly increase bone blood flow( P< 0 05).Conclusion: Lingustrazine and Garlicin may prevent steroid induced femoral head necrosis,and have good effect on early stage of the necrosis of femoral head.

关 键 词：股骨头坏死 放射性微球技术 药物疗法 中药 

分 类 号：R681.805[医药卫生—骨科学]