参地降糖颗粒对胰岛素抵抗的实验研究  

Lab study of Shendijiangtang Granula on Insulin Resistence

作　　者：王凌[1] 刘震[1] 李秋贵[1] 李怡[1] 李文瑞[1] 

机构地区：[1]卫生部北京医院,北京100730

出　　处：《世界中西医结合杂志》2007年第4期207-209,共3页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的:观察中药复方参地降糖颗粒在治疗2型糖尿病方面的疗效。方法:用具有胰岛素抵抗伴高血压的高果糖大鼠-FFR模型探讨肥胖因子(ob遗传子)的表达产物—瘦素(Leptin)的影响作用,以及参地降糖颗粒对瘦素的改善机制。结果:Leptin在FFR中明显高于正常对照组,参地降糖颗粒经口投喂FFR2w,能明显降低FFR增高的Leptin,提高胰岛素敏感性指标M值,恢复到与正常对照组近乎相等的程度。结论:中药复方参地降糖颗粒对2型糖尿病疗效明显。Objective： To study the effects of Shendijiangtang Granula on insulin resistance （IR）. Method： High fructoseand rats with hypertension and IR were used, and the mechanisms of plasma leptin was observed. Results： The content of leptin is higher than that of in control group; M value was also improved and it approached to the control. Conclusion, Shendijiangtang Granula has a good effect on IR.

关 键 词：参地降糖颗粒-JTKL 胰岛素抵抗-IR 高果糖大鼠-FFR 胰岛素敏感性指标-M值 瘦素-Leptin 脂质代谢 

分 类 号：R587.1[医药卫生—内分泌]