肾综合征出血热患者血小板功能、肝素样物质、AT-Ⅲ∶α的变化及相互关系  

The changes and relation among platelet function, plasma heparin and anti-coagulation-Ⅲ: activity in patients with hemorrhagic fever with renal syndrome

作　　者：魏来[1] 潘秀英[1] 俞幼知[1] 鹿群先[1] 

机构地区：[1]徐州医学院附属医院

出　　处：《中华实验和临床病毒学杂志》1997年第2期163-165,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：测定了５５例肾综合征出血热（ＨＦＲＳ）患者血小板计数、血小板粘附功能、血小板聚集功能、血浆肝素样物质含量及抗凝血酶－Ⅲ活性（ＡＴ－Ⅲ∶α）。结果表明，ＨＦＲＳ患者有显著的血小板计数降低，血小板粘附、聚集功能减弱，血肝素样物质含量增高与ＡＴ－Ⅲ∶α下降（Ｐ＜０．０５），在病程的极期与危重型患者，上述改变更为显著。相关分析表明，在ＡＴ－Ⅲ∶α＞８０％的患者，血肝素样物质含量与血小板计数、血小板粘附率及血小板聚集率之间的相关系数分别为－０．４３４４，－０．７１５７，－０．５５４７（Ｐ值均＜０．０１）。提示，ＨＦＲＳ患者血肝素样物质含量的增高可能是血小板数量减少与粘附、聚集功能减弱的原因之一，而这一影响作用在ＡＴ－Ⅲ∶α＞８０％的患者尤为显著。Blood platelet count (BPC), platelet adhesive rate (PAdT), platelet aggregate rate (PAgT), plasma heparin and anti-coagulation-Ⅲ: αctivity (AT-Ⅲ:α) were determined in 55 cases with hemorrhagic fever with renal syndrome (HFRS). In these patients, decreased BPC, defect PAdT, PAgT, increased plasma heparin as well as decreased AT-Ⅲ:α were found, moreover, these changes were much notable in patients with severe type. A positive correlation existed between plasma heparin and BPC, PAdT, PAgT in cases with 80% AT-Ⅲ:α or above (r values were -0 4344, - 7157 and -0 5547 respectly, p<0 01). The results suggested that plasma heparin may be one of factors resulting in decreased BPC and defect platelet function in HFRS patients with 80% AT-Ⅲ:α or above.

关 键 词：肾综合征出血热 血小板 抗凝血酶Ⅲ 

分 类 号：R512.8[医药卫生—内科学]