药物代谢性相互作用  

Metabolic Drug Interactions

作　　者：邹文[1] 周文[2] 

机构地区：[1]山东大学药学院,山东济南250012 [2]山东大学齐鲁医院,山东济南250012

出　　处：《食品与药品》2007年第12A期46-49,共4页Food and Drug

基　　金：山东省卫生厅科研基金资助课题(2005HZ044)

摘　　要：当前绝大多数患者都有多药合用的情况,药物相互作用所致的不良反应日趋严重,是医患双方均应认真考虑的一个重要且现实的问题。其中,以前知之甚少的药物代谢性相互作用更是关注的热点。认识药物代谢的酶学基础,了解药酶的常见底物、诱导剂和抑制剂,合理选用同类药品,能避免有害药物代谢性相互作用的发生。本文对药物代谢性相互作用的研究进展作一综述,以冀引起医务人员的重视,将药物因代谢性相互作用所致的不良反应减少到最低限度。Now the multi-drug therapy becomes common for most patients. The ADRs caused by drug interactions become more and more serious, which is an important fact for doctors and patients. So, the study on metabolic drug interactions, known a little before, is mainly a hot spot. The adverse drug interactions can be avoided by knowing the enzymology basis of drug metabolism, common substrates, inductors, inhibitors involved and using the same kind of drugs rationally. This article reviews the progress on metabolic drug interactions in order to cause the attention of medical staff and take measures to cut down the frequency of ADRs caused by unreasonable metabolic drug interactions.

关 键 词：药物代谢 药物相互作用 代谢酶 

分 类 号：R969.2[医药卫生—药理学]