乙型肝炎病毒感染对健康影响的队列研究  

A cohort study on the health effect by hepatitis B virus infection

作　　者：郁新森[1] 钱雪峰[1] 陆洪斌[1] 林文尧[1] 

机构地区：[1]海门市疾病预防控制中心,江苏海门226100

出　　处：《江苏预防医学》2007年第4期9-11,共3页Jiangsu Journal of Preventive Medicine

基　　金：国际合作项目(2P01Ca40737NCI.USA);国科遗办审字1999(002)

摘　　要：目的：探讨乙型肝炎病毒（HBV）感染对健康的影响。方法：在原发性肝癌（HCC）高发区江苏省海门市建立前瞻『生研究队列人群，对研究对象进行流行病学调查，采集外周静脉血检测HBsAg及其他相关指标，每年随访队列成员的生命状况及死因。以HBsAg作为HBV感染指标，比较HBsAg暴露和阴性组人群的死亡密度。并应用COX风险模型探讨HBV感染在原发性肝细胞癌（HCC）发生中的风险率比（HR）。结果：HBsAg暴露组人群的死亡密度为1482．35／10万人年，是对照组的3．42倍。HCC是研究组的首位死因，占全部死亡的52．28％，与对照组相比RR=15．63，AR=93．60％。男性HR=22．3，95％CI18．7～26．6，女性HR=37．2，95％CI=19．1～72．5。结论：感染HBV对机体健康有明显影响。Objective： To investigate the health status affected by hepatitis B virus （HBV） infection. Methods： A prospective cohort study was established in Ha/men City, a high endemic area of hepatocellular carcinoma （HCC） in Jiangsu Province. An epidemiological survey was performed for each research subject. Peripheral blood sample was collected to detect HBsAg and other related indicators. The vital status and cause of death of each cohort member was followed up once a year. Using HBsAg（＋） as the indicators of HBV infection, the whole cohort was divided into two groups, one was exposure group, the other was control group. By comparing the death density of these two groups, COX proportional hazard model was applied to evaluate the hazard ratio （HR） of HBV infection in the pathogenesis of HCC. Results： The death density of explore group was 1482. 35 per 10 thousand person a year, which was 3. 42 times of the control group. HCC was the leading cause of death in the research group and accounted for 52. 28~ of total deaths. Compared to the control group, the relative risk （RR） was 15. 63, the attributable risk （AR） was of 93. 60M; for males, HR was 22.3, 95%, CI ranged from 18. 7- 26. 6; HR was 37. 2,95M, CI ranged from 19. 1-72. 5 in females. Conclusion： HBV infection did take affect on body＇s health obviously.

关 键 词：HBV感染 死亡密度 队列研究 

分 类 号：R512.62[医药卫生—内科学]