罗哌卡因中胸段硬膜外术后镇痛的药效学  

Analgesic effects of Ropivacaine after surgery with epidural anesthesia in mid - thoracic

作　　者：刘安林[1] 黄波[1] 陈爱文[1] 姚虹[1] 李胜利[1] 黄梅平[1] 林小玲[1] 仇武君[1] 

机构地区：[1]广州医学院附属深圳沙井医院麻醉科,广东深圳518104

出　　处：《现代保健（医学创新研究）》2007年第12Z期14-15,共2页

基　　金：深圳市宝安区科技计划立项,编号200572

摘　　要：目的研究罗哌卡因用于中胸段硬膜外术后镇痛的药效学。方法择期行上腹部手术成年患者60例，随机分为6组，每组10例。采用全麻加硬膜外维持麻醉，术后患者自觉疼痛难忍时，给予硬膜外推注预设的不同浓度罗哌卡因药液8ml，注药时间2min，用药后15、30min进行VAS评分，对镇痛效果与药物浓度进行相关分析，通过probit转换，建立镇痛有效率-药物浓度的线性回归方程，计算罗哌卡因的Ec50和Ec95值。结果与结论罗哌卡因药物浓度与镇痛有效率呈高度直线相关（r=0.995，P〈0.01）。回归方程为：镇痛有效率（％）=728，57×药物浓度（％）-0.443，根据回归方程计算EC50=0．129％，EC95=0.191％。Objective To research epidural analgesia pharmacodynamics of ropivacaine used in mid - thoracic after operation. Methods 60 patients undergoing epigast surgery were randomly divided into 6 groups. Total anesthesia combined by epidural anesthesia was performed. After operation ,8ml ropivacaine was injected into epidural with different concentration in every group when patients could not tolerate pain. Time of injection is 2min. VAS value was recorded 15min and 30min after injection. Correlation analysis was carried out between analgesia effect and ropivacaine concentration and equation of linear regression was established between effective rate of analgesia and ropivacaine concentration in order to calculate EC50 and EC95 of ropivacaine. Results and Conclusions Effective analgesia rate is high linear correlate with ropivacaine concentration（ r =0.906, P〈0.01 ）. Regression equation is that effective analgesia rate （ % ） = 728.57×ropivacaine concentration （ % ） - 0： 443. Acorrding to regression equation,EC50 is 0. 129% and EC95 is 0. 191%.

关 键 词：罗哌卡因 镇痛 硬膜外 药效学胸段 

分 类 号：R614[医药卫生—麻醉学]