肿瘤坏死因子的基因多态性和脓毒症易感性  

Tumor necrosis factor gene polymorphism and sepsis susceptivity

作　　者：胡维信（综述）[1] 刘保池（审校）[1] 

机构地区：[1]郑州大学第一附属医院急诊科,郑州450000

出　　处：《世界急危重病医学杂志》2007年第6期2164-2167,共4页internationl journal of emergency and critical care medicine

摘　　要：位于人类主要组织相容性复合体Ⅲ类基因区内的TNF基因有多态性，这些多态性与个体对脓毒症的易感性、发展、预后密切相关。本文综述TNF基因多态性与脓毒症的关系，发现可以寻找判断预后的基因标志，还可以为脓毒症的免疫基因治疗奠定基础.TNF gene is located in human MHC-Ⅲ domain ,whose polymorphism has been proved to be closely correlated with individual＇s susceptivity,development and prognosis of sepsis.By reviewing the relationship of TNF gene polymorphism with sepsis, we found it is helpful to build the foundation of sepsis ＇s immuno genetic therapy besides searching it＇s genetic marker for prognostic judgement.

关 键 词：肿瘤坏死因子 基因多态性 脓毒症易感性 

分 类 号：R637[医药卫生—外科学]