血清脂质和载脂蛋白的变化在小儿肾小球疾病中的临床意义  

Clinical significance of change of serum lipid and apolipoprotein in children with glomerular diseases

作　　者：陈吉明 刘梅[2] 

机构地区：[1]云南省永善县人民医院检验科,657300 [2]昆明医学院第一附属医院儿科

出　　处：《检验医学与临床》2007年第12期1149-1150,共2页Laboratory Medicine and Clinic

摘　　要：目的为了解肾病综合征和急性肾炎患儿血清脂质、载脂蛋白(Apo)水平的变化情况。方法用生化的方法对23例肾病综合征,7例急性肾炎和15名健康儿童的血清脂质和Apo水平进行测定。结果肾病综合征患儿的血清胆固醇、三酰甘油和ApoB的水平明显高于急性肾炎和健康儿童(P<0.01);高密度脂蛋白和ApoA1水平与急性肾炎和健康儿童差异无统计学意义(P>0.05);活动期患儿ApoA1与ApoB(ApoA1/ApoB)的比值降低,肾炎性肾病患儿与单纯性肾病患儿相比血清脂质、Apo含量差异无统计学意义;小儿肾病综合征确实有血清脂代谢紊乱,单纯性和肾炎性肾病的变化是一致的,而且与肾炎性肾病患儿的血尿、高血压、氮质血症和补体C3降低与血清脂代谢紊乱无关。结论ApoA1与ApoB的比值降低是评价肾病病情变化的指标之一。Objective To explore the change of serum lipid and apolipoprotein in children with nephrotic syndrome and acute glomerulonephritis. Methods Biochemistry was used to detect the level of serum lipid and apolipoprotein in 23 cases of nephrotic syndrome, 7 cases of acute glomerulonephritis, 15 cases of healthy children respectively. Results The levels of total cholesteral（TC） ,triglyceride （TG） and apolipoprotein-B（ApoB） in nephritic syndrome were obviously higher than those in acute glomerulonephritis and healthy children（P〈0.01） , whereas the level of high density lipoprotein（HDL） and apolipoprotein-Al（ApoA1） had no statistical difference（P〈0.05）. The ratio of ApoA1 to ApoB in nephritic syndrome at active stage was low. There was no difference in serum lipid and apolipoprotein between glomerulonephritis and simple glomerular diseases. The metabolic disorder occured in nephritic syndrome. The metabolic disorders in glomerulonephritis were the same as that in simple glomerular diseases and had no relation with hematuria, hypertension, azotemia and low C3. Conclusion The fall of ratio of ApoA1 to ApoB is one of indexes evaluating the development of glomerular diseases.

关 键 词：肾小球疾病 血清脂质 载脂蛋白 

分 类 号：R692.6[医药卫生—泌尿科学]