a干扰素联合甘利欣治疗慢性乙型肝炎疗效观察  

Observing Curative Effect of α Interferon Combined with Ganlixin to Treat Chronic Hepatitis B

作　　者：李如成 庞立 陆学华 

机构地区：[1]广东省湛江农垦第二医院,广东湛江524272

出　　处：《河北医学》2007年第2期184-187,共4页Hebei Medicine

摘　　要：目的:观察a干扰素联合甘利欣治疗慢性乙型肝炎的疗效。方法:治疗组予a干扰素500万U单位,肌注,1次/d×30 d;后改为隔日1次,总疗程为6个月,同时口服甘利欣胶囊150 mg,3次/d,疗程为6个月。对照组采用干扰素,剂量方法同前。治疗前后分别检测ALT、HBV-DNA、HBeAg、抗-HBc。一年后分别测定两组的HBV-DNA、HBeAg复阳率。结果:治疗组治愈率和显效率、ALT复常率、HBV-DNA、HBeAg阴转率及抗-HBc转阴率均较对照组明显增高;治疗1年后治疗组患者血清HBeAg和HBV-DNA复阳率较对照组明显下降。结论:a干扰素联合甘利欣治疗慢性乙肝近期和远期疗效好,复发率低。Objective： To observe curative effect of ct interferon combined with Ganlixin to treat chronic hepatitis B. Method： The treatment group was given α interferon of 5 million U unit for muscle injection for one time/d for 30 days, and then one time every other day for 6 months as a period of treatment, also given Ganlixin capsule 150 mg,3 times/days for 6 months orally taking as a period of treatment; The comparison group uses interferon as above method in same dosage method. The ALT, HBV DNA, HBeAg and anti - HBc are tested for two groups of patients before and after the treatment; the positive recovery rate of HBV DNA,HBeAg is tested in one year separately. Result： The curing rate, evident effect rate, ALT recovery rate, HBV DNA, HBeAg negative changing rate and anti - positive - HBc negative changing rate are higher than that of the comparison group; the positive changing rate of serum HBeAg and HBV DNA is evident low- er than the comparison group. Conclusion： The curative effect of treatment for α interferon combined with Ganlixin to treat chronic hepatitis B is better for recent and long period, which is lover recovery rate.

关 键 词：A干扰素 甘利欣 慢性乙型肝炎 

分 类 号：R512.62[医药卫生—内科学]