静脉应用胺碘酮致急性肝损害及其转归  

Intraverous Amiodarone-related Hepatotoxicity to Treat Tachycardia Arrhythma

作　　者：徐国帆[1] 陈聪[1] 叶海鹏[1] 陈杰山[1] 梁岩[1] 

机构地区：[1]广东省茂名市人民医院心内科,广东茂名525000

出　　处：《河北医学》2007年第5期578-580,共3页Hebei Medicine

摘　　要：目的:研究静脉应用胺碘酮治疗快速心律失常导致的急性肝损害及其转归。方法:观察静脉用胺碘酮治疗快速心律失常导致急性肝损害例的临床表现、肝脏生化指标的变化及其临床转归。结果:9例患者出现肝脏损坏时静脉胺碘酮累积量平均为1392.7mg,首日负荷量平均为182.6mg。用药后9例次日转氨酶即开始升高,d3达峰值,患者无临床症状,停药后保肝治疗,约八周转氨酶降至正常,无因肝损害死亡病例。结论:静脉应用胺碘酮可以引起急性肝损害,尽管少见但具有潜在的致命性,因此监测肝脏功能是有必要的。Objective： To study hepatotoxicity in tachycardia arrhythma with intraverous amiodarone. Method： To observe 9 cases characters of clinical and biochemistry with acute liver impaired induced by inravenous amiodarone. Result： Liver enzymes（ ALT, AST） raised when average cumulative dose is 1392. 7mg, only two paitents have symptoms. ALT and AST droped to normal level after intraverous amiodarone were stopped about 8 weeks in most patients. Conclusion： Intraverous amiodarone - related hepatotoxicity is rare, but it has fatal feature. Therefore, patients will be monitored to test liver enzme after intravenous amiodarone.

关 键 词：心律失常 胺碘酮 药物毒性 

分 类 号：R541.7[医药卫生—心血管疾病]