甲氨蝶呤联合米非司酮治疗异位妊娠的疗效观察  

Observation on the Curative Effect of MTX Combined with Mifepristone on Ectopic Pregnancy

作　　者：雷萍[1] 雷瑛[1] 

机构地区：[1]广东省珠海市妇幼保健院,广东珠海519000

出　　处：《河北医学》2007年第4期411-414,共4页Hebei Medicine

摘　　要：目的:观察甲氨蝶呤(MTX)联合米非司酮治疗输卵管妊娠的疗效。方法:A组28例患者应用MTX单次肌内注射并口服米非司酮药物治疗为观察组;B组28例患者MTX(50mg/m2)单次肌内注射为对照组。两组均于用药后d5监测血β-HCG水平及阴道B超监测包块情况直至正常。结果:两组成功率分别为84.6%,73.7%,两组在年龄、孕龄、治疗前血HCG值和异位妊娠包块直径间差异无显著性(P>0.05)。A组较B组明显缩短血HCG降至正常所需的时间,减少住院日(P<0.01)。结论:MTX单次肌内注射联合米非司酮治疗输卵管妊娠的疗效好,值得推广。Objective： To seek an effective, simple and highly successful conservative method that no negative effect on thief reproductive function in patients with ectopic pregnancy. Method： A total of 56 cases of ectopic pregnacy were diagnosed as unrupture tubal pregnancy that be divided into two groups. Group A was treated with （ MTX ） single - dose （ 50mg/m^2 ） intramuscular injection combined with oral Mifeprislone （ Ru486 ）. Group B treated with MTX single - dose （ 50 mg/m2 ） intramuscular injection only. After treat- ment, the serum β - HCG levels and transvaginal B - ultrasonic inspection were examined until return to normal level. Result： The curative rate was 85.7%, 67.8% in Group A and Group B, separately. The shorten time that 13 - HCG retum to normal level , less time of hospitalization in Group A significantly dif- fered from Group B （ P 〈0.01 ）. Conclusion ： The combination of single - dose MTX intramuscular injection with oral mifepristone （ Ru486 ） in treating tubas pregnancy is a highly effective. It was worth to popularizing in clinical practice.

关 键 词：异位妊娠 药物治疗 甲氨蝶呤 米非司酮 

分 类 号：R714.22[医药卫生—妇产科学]