甲状腺功能减退性多发性肌炎样综合征57例回顾分析  

Retrospective analysis of fifty-seven cases of polymyositis-like syndrome in hypothyroidism patients

作　　者：戴冽[1] 郑东辉[1] 莫颖倩[1] 吴毅梅[1] 张白玉[1] 

机构地区：[1]中山大学附属第二医院风湿免疫科,广州510120

出　　处：《中华风湿病学杂志》2007年第12期738-741,共4页Chinese Journal of Rheumatology

摘　　要：目的了解甲状腺功能减退性多发性肌炎样综合征患者的临床特点。方法回顾分析1997--2007年国内文献报道的53例及我院收治的4例患者的临床资料。结果甲状腺功能减退性多发性肌炎样综合征表现为近端肌无力伴不同程度肌痛，不伴肌肥大或肌强直，肌酶显著升高，肌电图和肌活检多无特异性改变，甲状腺素替代治疗疗效好。结论临床上对有肌病表现、肌酶显著升高的患者须注意有无甲状腺功能减退症。病程较长、病情严重或伴黏液性水肿的甲状腺功能减退症患者出现特异性肌肉表现、肌酶显著升高时应考虑多发性肌炎样综合征。Objective To improve the understanding of the polymyositis-like syndrome in hypothyroidism patients. Methods Clinical data of 57 cases were reviewed retrospectively. Results The syndrome showed proximal muscle weakness with myalgia and elevation of creatine kinase （CK） level, without evidence of muscular hypertrophy and stiffness. Electromyography and muscle biopsy revealed nonspecific changes. All patients showed clinical recovery and resolution of the laboratory abnormalities after thyroid hormone replacement. Conclusions Hypothyroidism should be routinely screened in patients with muscle weakness and elevation of CK. Polymyositis-like syndrome should be considered in patients with severe hypothyroidism in case of muscle weakness and elevation of serum CK level.

关 键 词：甲状腺功能减退症 多发性肌炎 多发性肌炎样综合征 甲状腺功能减退性肌病 

分 类 号：R686[医药卫生—骨科学]