中药异位宁对子宫内膜异位症模型大鼠Fas/FasL基因表达影响的实验研究  

Empirical study of effect of Yiwei Ning on expression of Fas/FasL in rat with endometriosis

作　　者：马文光[1] 徐晓宇[1] 谭文华[2] 曲凡[1] 马宝璋[1] 

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]哈尔滨医科大学附属第二医院,哈尔滨150080

出　　处：《中华中医药杂志》2007年第12期879-881,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：黑龙江省自然科学基金资助项目(No.D2004-55);国家教育部高等学校博士学科点专题科研基金资助项目(No.20050228001)

摘　　要：目的:通过研究异位宁对Fas/FasL蛋白表达的影响来阐述异位宁治疗子宫内膜异位症的作用机制。方法:取雌性Wistar大鼠,随机分为5组,正常对照组、模型对照组、异位宁高、低剂量组及西药丹那唑对照组;造模成功后各给药组灌胃给药1个月后,观察各组子宫内膜局部组织中Fas及FasL蛋白的表达情况。结果:治疗后异位宁高、低剂量组以及西药对照组Fas、FasL表达增多,染色较深,与模型组比较有显著性差异(P<0.05)。结论:异位宁具有诱导Fas、FasL基因表达,提高异位内膜凋亡能力,使异位病灶得以萎缩、消失的作用。Objective： To expound the effect of Yiwei Ning in treating endometriosis through measuring Fas/ FasL protein expression. Method： The female Wistar rats were divided into five groups randomly. After 8 weeks of administration, expression of Fas/FasL protein were determined . Results： There were significant difference in the positive expression of Fas/FasL protein between Yiwei Ning group and the control group （ P 〈 0.05）. Conclusion： Yiwei Ning could induce the expression of Fas/FasL gene, facilitate the cell apoptosis of the ectopic endometrium, which make the ectopic endometrium atrophy and disappear.

关 键 词：子宫内膜异位症 中药异位宁 FAS/FASL 蛋白表达 凋亡基因 实验研究 

分 类 号：R285.5[医药卫生—中药学]