单项抗-HEV-IgG阳性对急性戊型肝炎的临床诊断价值及其血清学特征  

Clinical diagnostic value of single anti-hepatitis E virus IgG positive for acute hepatitis E

作　　者：刘婷[1] 柯伟民[1] 赖菁 朱睛 

机构地区：[1]广州市中山大学第三附属医院感染病学教研室,510630 [2]广东省新兴县人民医院感染病科

出　　处：《实用肝脏病杂志》2007年第6期395-397,共3页Journal of Practical Hepatology

摘　　要：目的探讨单项抗-HEV-IgG阳性对急性戊型肝炎的临床诊断价值。方法收集连续收治的非甲～非丁型急性肝炎患者168例,其中仅抗-HEV-IgG阳性而抗-HEV-IgM阴性者53例,而抗-HEV-IgM/抗-HEV-IgG阳性115例,分析比较了他们的年龄、肝功能、肝脾B型超声波检查情况。结果在168例非甲～非丁型急性肝炎患者中,有31.55%(53/168)患者从第1病周至第6病周以上仅检测到抗-HEV-IgG阳性,而抗-HEV-IgM阴性;68.45%(115/168)患者抗-HEV-IgM/抗-HEV-IgG阳性。53例单项抗-HEV-IgG阳性者与115例抗-HEV-IgM/抗-HEV-IgG阳性者的年龄、肝功能和肝脾B型超声波检查指标的比较,两组之间均无显著性差异(P=0.311～0.976)。结论使用人工合成的戊型肝炎病毒开放阅读区1和2编码的重组多肽抗原检测抗-HEV-IgM和IgG,如果单项抗-HEV-IgG阳性、有急性病毒性肝炎的肝功能改变,并能排除其他病因者,可以临床诊断急性戊型肝炎。Objective To evaluate the significances of single hepatitis E virus antibody IgG anti-HEV IgG） positive for the clinical diagnostic value of acute hepatitis E. Methods Anti-HEV- IgM and IgG were detected in the consecutive one hundred and sixty-eight patients with non-A to non-D acute hepatitis. Results Out of the one hundred and sixtyeight patients, 31. 55% （53/168） were only detected with anti-HEV-IgG positive and 68. 15% （115/ 168） with antiHEV-IgM and anti-HEV-IgG positive. There was no statistically difference between the average ages, liver function tests and hepatospienic image changes by B model ultrasound detection between the two groups （P =0. 311-0. 976）. Conclusion The diagnosis of acute hepatitis E with single anti-HEV-IgG positive should be considered when there is a typical clinical features, changes of liver functions, and no other etiologic causes.

关 键 词：戊型肝炎 抗-HEV—IgM 抗HEV—IgG 临床资料 

分 类 号：R512.6[医药卫生—内科学]