胰岛素、罗格列酮对2型糖尿病大血管病变患者外周血MMP-9,hsC-RP和WBC计数的影响  

The effects of insulin and rosiglitazone on the levels of MMP-9,hsCRP and WBC count in type 2 diabetic patients with macroangiopathy

作　　者：李佳[1] 何建华[1] 杨军[1] 

机构地区：[1]泸州医学院附属医院内分泌科,四川646000

出　　处：《中国糖尿病杂志》2007年第11期666-669,共4页Chinese Journal of Diabetes

摘　　要：目的评价胰岛素、罗格列酮(RSG)治疗对2型糖尿病(T2DM)大血管病变患者外周血基质金属蛋白酶9(MMP-9)、高敏C反应蛋白(hsC-RP)、外周血白细胞(WBC)计数的影响。方法将80例T2DM大血管病变患者随机分为对照组和治疗组并分别测定血清MMP-9、hsC-RP水平及其他临床指标。对照组以胰岛素、治疗组用胰岛素加RSG(4mg/d)降糖,治疗12周后复查各指标。结果T2DM大血管病变者外周血MMP-9与hsC-RP、WBC呈正相关。胰岛素加用RSG治疗12周使三者明显下降,与基线和单用胰岛素的对照组相比差异有统计学意义。对照组MMP-9、hsC-RP的下降与HbA1c的改变明显相关。结论RSG能明显降低T2DM大血管病变者外周血MMP-9、hsC-RP、WBC计数,胰岛素也能降低MMP-9、hsC-RP水平,两者合用更能发挥有益的抗动脉粥样硬化的作用。Objective To investigate the effects of rosiglitazone（RSG） and insulin on the levels of MMP-9,hsC-RP and WBC count in type 2 diabetic patients with macroangiopathy. Methods The serum levels of MMP-9,hsC-RP and the other clinical parameters were determined in 80 type 2 diabetic patients with macroangiopathy. All patients were randomized to groups of receiving insulin plus RSG（4mg/d） or insulin alone for 12 weeks. Results In type 2 diabetic patients with macroangiopathy,the serum MMP-9 was significantly correlated positively with C-RP and WBC. The RSG plus insulin treament significantly reduced levels of MMP-9, C-RP and WBC after 12 weeks. In control group, the reduction of MMP-9 and C-RP were correlated positively with HbA1c. Conclusions RSG plus insulin can reduce significantly the levels of MMP-9, C-RP and WBC in T2DM patients with macroangiopathy, which indicates beneficial effects on overall macrovascular risk.

关 键 词：基质金属蛋白酶9 C反应蛋白 高敏 糖尿病 2型 罗格列酮 胰岛素 

分 类 号：R587.2[医药卫生—内分泌]