加味茵陈汤防治大鼠急性肝功能衰竭的实验研究  

Experimental Study on Modified Oriental Wormwood Decoction in Prevention of Acute Liver Failure Rats

作　　者：张金卷[1] 杜智[1] 张淑萍[1] 朱争艳[1] 王毅军[1] 聂福华[1] 宋继昌[1] 

机构地区：[1]天津市第三中心医院肝胆外科,天津300170

出　　处：《中国中西医结合外科杂志》2007年第6期559-562,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:探索中药加味茵陈汤对急性肝功能衰竭大鼠的防治效果。方法:加味茵陈汤汤剂(2g/mL),Wistar大鼠D-氨基半乳糖腹腔内一次注射(剂量1200mg/kg),分别以不同剂量中药灌胃(A组45g/kg;B组30g/kg;C组15g/kg),对照组(D组)给予相同体积生理盐水。观察一般情况改变及生存时间,于给药前、给药后24h、48h、72h取血测定血氨、AST、ALT及TBil,并取肝脏进行病理检查。结果:随中药剂量增加模型大鼠中位生存时间延长,A、B组与D组间比均有统计学差异(P<0.05)。C组及D组血氨、AST、ALT及TBil水平明显高于A、B两组,且D组高于C组(P<0.05)。A、B两组大鼠肝脏病理结果改善,均较D组坏死轻。结论:中药加味茵陈汤可以延长D-氨基半乳诱导大鼠急性肝功能衰竭模型的生存时间,改善TBiL及血氨等肝功能指标,减轻肝脏损伤的病理改变。Objective To study the therapeutic effect of modified oriental wormwood decoction （MOWD） in the treatment of liver failure（ALF） rats Methods The ALF rats induced by D-GaIN （120 mg/kg ） were given MOWD（2 g/ml） by gavage at different dosage（group A 45 g/kg B.W., group B 30 g/kg B/W., group C 15 g/kg B.W. ） b.i. d. beginning on the time after D-GaIN injection, Serum ALT, AST Tbil and blood ammonia levels were measured before and after the injection at different time points, and control group were given same volume of NS. Results The survival time of MOWD treated rats in group A and B was longer than that in control group （ P 〈 0.05）. There was no significant difference in biochemical parameters levels among different groups before MOWD administration, and the level of group A and B were lower than that in control group at each time points after administration. But there was no significant difference between group A and B. The pathological injuries of liver were improved in group A and B. Conclusion The administration of MOWD can improve the survival time, biochemicall disorders and liver necrosis in ALF rats.

关 键 词：加味茵陈汤 急性肝功能衰竭 大鼠 

分 类 号：R285.6[医药卫生—中药学] R657.3[医药卫生—中医学]