高龄髋关节术后镇痛与全身炎症反应综合征相关性研究  

Correlation studies on SIRS and ease pain after operation of hip joint among senile patients

作　　者：侯宝君[1] 安静[1] 张洪林[1] 史计月[1] 王文格[1] 

机构地区：[1]河北工程大学附属医院,河北邯郸056029

出　　处：《山东医药》2007年第32期31-33,共3页Shandong Medical Journal

基　　金：河北省科技厅科研立项课题(20042761484);河北省卫生厅重大医学研究资助课题(05331)

摘　　要：目的观察高龄髋关节手术后镇痛与全身炎症反应综合征（SIRS）间的相关性。方法将32例65～90岁髋关节手术患者随机分为M组和E组，术后分别采取肌注镇痛和硬膜外自控镇痛，观察肿瘤坏死因子（TNF-α）、白介素6（IL-6）水平变化，并行视觉模拟评分（VAS）与SIRS评分。结果两组TNF-α和IL-6术后均较术前升高，M组持续到术后24h达峰值，E组术后24h水平明显低于M组（P〈0.05）；E组术后各时间点VAS与SIRS评分均明显低于M组。结论高龄髋关节术后应用硬膜外自控镇痛有效降低疼痛强度同时，显著抑制TNF-α、IL-6等释放，有效防治术后SIRS的发生与发展。[ Objective] To study the correlation of systemtic inflammatory response syndrome （SIRS） and ease pain after operation of hip joint among senile patients. [ Methods ] The 32 cases after hip joint surgery were randomly divided into M and E group, postopratively patient controlled extradural analgesia and intramuscular analgesia respectively. The changes of blood serum TNF-α, IL-6 level were measured according to visual analogy score（VAS） and SIRS scale. [ Re- suits ] A rise in the levels of TNF-α and IL-6 in two groups postoperatively was observed, but there were significant difference in the levels of TNF-α and IL-6 in two groups （ P 〈 0.05）. The scores of VAS and SIRS were also lower in group E all the time （ P 〈0.05, or P 〈0.01 ）. [ Conclusion] Patient controlled extradural analgesia could inhibit the release of cytokines as TNF-α and IL-6 etc and decrease the occurrence of complications such as SIRS.

关 键 词：髋关节手术 硬膜外自控镇痛 全身炎症反应综合征 

分 类 号：R683.3[医药卫生—骨科学]