有偿献血者HIV-1、HCV、HBV合并感染调查  

Investigation on HIV-1 co-infection with HCV and HBV in commercial blood donators

作　　者：董瑞玲[1,2] 汪宁[1] 乔晓春[3] 丁国伟[1] 贾望谦[4] 施小明[5] Qian Hanzhu 乌正赉[7] 郑锡文[1] 

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心,北京100050 [2]北京协和医学院公共卫生学院 [3]山西省疾病预防控制中心 [4]山西省闻喜县疾病预防控制中心 [5]中国疾病预防控制中心慢性病防治与社区卫生处 [6]Universjty of Alabama at Birmingham,USA [7]北京协和医学院基础医学院

出　　处：《中国公共卫生》2007年第12期1420-1422,共3页Chinese Journal of Public Health

基　　金：中国综合性艾滋病研究项目(CIPRA;美国国立卫生研究院国家传染病与变态反应研究所资助;U19A151915)

摘　　要：目的调查山西省农村某既往有偿献血地区人类免疫缺陷病毒（HIV）、丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）合并感染状况。方法对4个村年龄18～59岁的村民进行问卷调查和血样采集，检测项目包括HIV-1抗体、HCV抗体和HBV表面抗原（HBsAg）。结果人群HIV、HCV、HBV感染率分别为1．3％（40／3062），12．7％（389／3062），3．5％（103／2982）；40名HIV感染者中，85．0％伴HCV感染，2．5％伴HBV感染。多因素Logistic回归分析提示，既往有偿献血（浆）史是HIV、HCV及HIV／HCV合并感染的危险因素，而与HBsAg阳性呈负相关，过去5年外出打工史与HIV、HBsAg、HIV／HCV感染差异有统计学意义；未发现吸毒、终生性伴数、婚外性行为、商业性行为和各种性行为中安全套的使用与HIV、HCV、HBV感染及合并感染有关联。结论应重点关注HIV、HCV和HBV感染者的治疗、健康教育和行为干预。Objective To evaluate prevalence of and risk factors for human immunodeficiency virvs（HIV） co - infection with hepatitis C virus（HCV） and hepatitis B virus（HBV） in rural commercial blood donation area in Shanxi province, China. Methods A cross- sectional study was conducted and all residents aged 18～59 years in four villages in a county of Shanxi province were invited for questionnaire interview and testing of HIV, HCV antibody and hepatitis B virus surface antigen（ HBsAg）. Results A total of 3 062 villagers participated in this study and provided specimens for related testing. Seroprevalence of anti - HIV anti - HCV and HBsAg were 1.3 % （40/3 062）, 12.7 % （389/3 062） and 3.5 % （ 103/2 982）, respectively of the 40 anti - HIV seropositive participants, 85.0 % were anti - HCV seropositive, 2.5 % were HBsAg seropositive. History of commercial blood donation was positively associated with anti- HIV seropositivity anti - HCV seropositivity and HIV/HCV co-infection （all HIV/HCV co-infected participants were blood donors）, but were negatively associated with HBsAg seropositivity. Migrated for work in last 5 years was positively associated with HIV, HBsAg seropositivity and HIV/HCV co - infection. Univariate analysis showed illegal drug use, number of sex partners, extramarital sex behavior, commercial sex behavior and condom use rate didn＇t associated with anti - HIV, anti - HCV HBsAg seropositvity and their co - infection. Conclusion History of commercial blood donation was main risk factor for HIV and HCV infection in this former commercial blood donation area.

关 键 词：人类免疫缺陷病毒 合并感染 丙型肝炎病毒 乙肝炎病毒表面抗原 有偿献血 

分 类 号：R183.7[医药卫生—流行病学]