2型糖尿病患者遗传性病例对照研究  

Case-control study on genetic factors of type 2 diabetes mellitus

作　　者：张绍维[1] 李鹏飞[2] 孙文娟[2] 王雨[2] 殷明月[2] 

机构地区：[1]沈阳军区202医院,沈阳110001 [2]沈阳医学院

出　　处：《中国公共卫生》2007年第12期1463-1464,共2页Chinese Journal of Public Health

摘　　要：目的通过对2型糖尿病一级亲属患病率和遗传度的分析，探讨遗传因素在2型糖尿病中的作用。方法采用病例对照方法，选择沈阳市2所医院门诊与住院的2型糖尿病患者203例作为病例组，同期选取社区缝康人群201人作为对照组进行调查。采用χ^2检验进行统计分析，并用Falconer法计算遗传度。结果家族史是2型糖尿病的危险因素（OR=5．89）；病例组一级亲属的2型糖尿病患病率为6。76％，显著高于对照组的1.27％，相对危险度为5．32（95％CI=3.54～7．99）；2型糖尿病一级亲属的遗传度为56．88％。结论遗传因素在2型糖尿病的发生中起重要作用，其一级亲属对糖尿病的遗传易感性较高，是糖尿病预防和控制的重点人群。Objective To study the prevalence rate and heritability in the first degree relatives of type 2 diabetes mellitus （DM） in Shenyang, to estimate the effect of genetic factors in type 2 diabetes mellitus. Methods On the basis of the survey of type 2 diabetes mellitus in hospital population and urban community population of Shenyang（203 cases and 201 controls）, a case - control study was carried out. Chi square test was used for data analysis and the Falconer was used to calculate the heritability. Results The family history was the risk factor of type 2 diabetes mellitus（ OR = 5.89）. The prevalence rate in the first degree relatives of index cases was 6.76 %, higher than the controls of 1.27 %, the risk ratio（RR） was 5.32 （95 % CI = 3.54～7.99, ）. The heritability was 56.88%. Conclusion Genetic factors make an important role in type 2 diabetes mellitus, and higher genetics susceptibility were found in the first degree relatives of DM, on whom prevention and treatment for DM should be focused.

关 键 词：2型糖尿病 病例对照研究 遗传 

分 类 号：R181.33[医药卫生—流行病学]