济南市居民高尿酸血症及影响因素分析  

Analysis on hyperuricemia and its influential factors in population

作　　者：温晓燕[1] 路方红[1] 杨建民[1] 刘振东[1] 周晓红[1] 金世宽[1] 王舒健[1] 

机构地区：[1]山东省医学科学院基础医学研究所,济南250062

出　　处：《中国公共卫生》2007年第12期1520-1522,共3页Chinese Journal of Public Health

摘　　要：目的调查济南市35～64岁人群高尿酸血症患病率并对其相关因素进行分析。方法对4041例健康查体人群进行横断面调查，应用Logistic回归模型分析影响因素与高尿酸血症的相关性。结果男性高尿酸血症患病人数为126例，患病率为6．4％；女性44例，患病率为2．1％。Logistic多元回归模型显示，高甘油三酯血症（OR=6．155）、高胆固醇血症（OR=2．853）、男性（OR=2．749）、高血压（OR=1．884）、腹型肥胖（OR=1．834）与高尿酸血症升高相关；农村人群（OR=0．266）、饮酒者（OR=0．807）则与高尿酸血症降低相关。结论济南市人群高尿酸血症发病率较低；高甘油三酯血症、高胆固醇血症、男性、高血压、腹型肥胖可能为高尿酸血症的危险因素；农村、适量饮酒可能为保护因素。Objective To investigate the prevalence of hyperuricemia and its risk factors in the general adult population aged 35 ～ 64 years in Jinan. Methods To analyze data on 4 041 residents aged 35 ～ 64 years from the cross - sectional survey of Jinan. Physical examination was carried out and fasting blood was tested. Data were analyzed by multivariate Logistic regression models. Results 1 979 men and 2 062 women participanted in the study. 6.4 % of men and 2.1% of women had hyperuricemia, which was defined as serum uric acid ≥417 μmol/L in men and ≥357 μmol/L in women. Multivariate Logistic regression models found that hypertriglyceridemia（ OR 6.155, 95 % CI 4. 354～8. 701 ）, hypercholesteremia（ OR 2. 853, 95% CI 1.796～4.531）, male gender（ OR 2.749, 95% CI 1.781 ～ 4.245）, hypertension（ OR 1.884, 95% CI 1.320 ～ 2. 687）, central obesity（ OR 1. 834, 95 % CI 1. 209 ～ 2. 781 ） were associated with increased risk of hyperuricemia, however, living in rural areas（OR 0.266,95% CI 0.177～0.398）and alcohol consumption（OR 0.807,95% CI 0.706～70.892）were associated with reduced risk of hyperuricemia. Conclusion Hypertriglyceridemia, hypercholesteremia, male gender, hypertension, central obesity are associated with increased risk of hyperuricemia. Alcohol consumption and living in rural areas are associated with reduced risk of hyperuricemia.

关 键 词：高尿酸血症 影响因素 流行病学 

分 类 号：R181.38[医药卫生—流行病学]