新烟碱类杀虫剂定量构效关系及杀虫作用机理的研究进展  

Review of Studies on the QSAR and Mechanism of Neonicotinoid Insecticides

作　　者：彭鑫林[1] 王辉宪[1] 姜晖霞[1] 周华[1] 刘邦夫[1] 罗启枚[1] 

机构地区：[1]湖南农业大学理学院应用化学系,长沙410128

出　　处：《现代农药》2007年第6期1-6,共6页MODERN AGROCHEMICALS

基　　金：湖南省自然科学基金资助项目(03JJY3017)

摘　　要：综述了烟碱、烟碱类似物和新烟碱类杀虫剂的定量构效关系及其杀虫作用机理的研究进展,重点介绍了新烟碱类杀虫剂与烟碱样乙酰胆碱受体的结合模型,并指出在对新烟碱类杀虫剂构效关系进行深入研究的基础上,从分子水平对其作用机理进行研究,将为解决新烟碱类杀虫剂存在的问题,更好地应用、开发此类杀虫剂提供理论基础。In this article the advances in research on the QSAR and mechanism of nicotine and nicotine analogues and neonicotinoid insecticides were reviewed. The paper lay emphasis on the binding model of neonicotinoid insecticides and nicotine acetylcholine receptors （nAChRs）. And it was pointed out that the studying on the effect mechanism of neonicotinoid insecticides from molecule level, on the basis the deeply studying of the SAR of neonicotinoid insecticides, would provide a theoretical basis for resolving some problems on neonicotinoid insecticides, applying and developing them much better.

关 键 词：新烟碱类杀虫剂 烟碱样乙酰胆碱受体 作用机理 定量构效关系 

分 类 号：TQ450.21[化学工程—农药化工]