蜂毒溶血肽作用机理研究进展  

Progress in biological mechanism of melittin

作　　者：赵亚华[1] 刘霭珊[1] 李日清[1] 高向阳[1] 张微[1] 郑慧平[1] 

机构地区：[1]华南农业大学生命科学学院,广州510642

出　　处：《昆虫学报》2007年第7期737-744,共8页Acta Entomologica Sinica

基　　金：国家自然科学基金项目(30570036);山东省教育厅科技计划重点项目(J06I04)

摘　　要：该文系统归纳了蜂毒溶血肽的生物学功能,分子结构与性质,溶解血细胞的机理,以及溶血和抑菌活性与结构的关系,并结合本实验室研究着重综述了近年来国内外对蜂毒溶血肽作用机理的研究。提出今后研究应该向定量化方向发展,应用计算技术深入阐明蜂毒肽作用的动力学过程及结构与功能的关系,为今后指导分子设计打下一定的理论基础。We summarized progress in melittin, including the biological function, the molecular structure and characteristics, the mechanism of hemolysis and the relationship between the structure and the activity of hemolysis and antimicrobial of melittin. Meanwhile, based on the related research in our laboratory, we focused on the studies of the mechanism of melittin home and abroad in recent years. We proposed that the study on melittin should be quantified, and the calculation technology should be utilized for further illustrating the dynamical process of melittin and the relationship between structure and function, which may provide a firm theoretical basis for guiding molecular designing in future.

关 键 词：蜂毒溶血肽 生物活性 分子结构 构效关系 作用机理 

分 类 号：Q786[生物学—分子生物学]