丙型肝炎病毒RNA定量检测与抗-HCV及ALT的关系  

Relationship between quantitative detection of HCV RNA and anti - HCV or ALT

作　　者：岳峰[1] 沈敦[1] 李冬茹[1] 

机构地区：[1]河南科技大学第一附属医院,洛阳471003

出　　处：《中原医刊》2007年第23期3-4,共2页Central Plains Medical Journal

摘　　要：目的了解丙型肝炎病毒核糖核酸（HCV RNA）定量与丙型肝炎病毒抗体（抗-HCV）及丙氨酸氨基转移酶（ALT）的关系。方法用荧光定量逆转录聚合酶反应（FQ—RT—PCR）检测239例抗-HCV阳性者的HCVRNA定量，同时检测ALT水平。结果239例中，150例（62．8％）HCV RNA定量高于80拷贝／ml；133例ALT异常，其异常率随HCV RNA定量的升高而增加。ALT异常例数与正常例数差异有统计学意义（P〈0．01），ALT水平与HCVRNA定量无相关性（r=0．524，P〉0．05），而ALT异常率与HCV RNA定量呈正相关（r=0．955，P〈0．05）。结论HCV RNA是反映HCV复制的可靠指标，结合ALT结果可帮助了解HCV在体内复制状况。Objective To evaluate the relationship of Hepatitis C Virus RNA （HCV RNA） and Antibody of HCV （Anti - HCV） and Alanine aminotransferase （ALT）. Methods The HCV RNA was detected in 239 hepatitis C patients using fluorescent quantitative reverse transcription polymerase chain reaction （ FQ - RT - PCR） and ALT level was measured. Results There were 150 （62.8%） cases of 239 with quantification of HCV RNA higher than 80 copy/ml. 133 cases of 239 were abnormal in ALT and abnormal rate increase with increasing quantification of HCV RNA. The rate of abnormal cases of ALT was significantly different from the normal cases. ALT level did not correlate with quantification of HCV RNA. The abnormal rate of ALT was close correlated with quantification of HCV RNA （ r = 0. 955, P 〈 0.05）. Conclusion HCV RNA is a reliable marker of replication. ALT level reflects replication status of HCV.

关 键 词：丙型肝炎病毒 核糖核酸定量 丙型肝炎病毒抗体 丙氨酸氨基转移酶 

分 类 号：R4[医药卫生—临床医学] R51