高血压病患者颈动脉粥样硬化与血清C-反应蛋白水平的关系  

Relationship between serum C-reactive protein level and carotid atherosclerosis in patients with essential hypertension

作　　者：焦东梅[1] 李伟[1] 武尚文[1] 肖振忠[1] 

机构地区：[1]山东中医药大学第二附属医院肾内科,山东济南250001

出　　处：《泰山医学院学报》2007年第3期165-167,共3页Journal of Taishan Medical College

摘　　要：目的探讨高血压病患者中颈动脉粥样硬化的发生与炎症标记物血清C-反应蛋白(CRP)的关系。方法对来院就诊的180例高血压病患者进行颈动脉超声检查,测量颈总动脉内中膜厚度(IMT)、观察有无颈动脉斑块形成,从而判断有无颈动脉粥样硬化;同时进行血清CRP浓度的测定。分析血清CRP与颈动脉粥样硬化、颈总动脉内中膜厚度(IMT)、颈动脉斑块指数(PI)之间的关系。结果①合并颈动脉粥样硬化的高血压病患者血清CRP显著高于无颈动脉粥样硬化患者[(5.25±5.69)mg/L vs(3.36±2.07)mg/L,P<0.01]。②颈动脉斑块组患者血清CRP显著高于颈动脉内中膜正常者[(6.37±5.15)mg/Lvs(3.36±2.07)mg/L,P<0.01];③斑块指数(PI)2级、3级患者血清CRP明显高于斑块指数0级的患者(P<0.01)。结论血清CRP与高血压病患者颈动脉粥样硬化的发生密切相关,炎症反应可能在高血压导致的外周动脉粥样硬化中发挥着重要作用。Objective：To investigate the relationship between serum C-reactive protein（CRP） level and carotid atherosclerosis in patients with essential hypertension.Methods： The serum concentrations of C-reactive protein（CRP） were measured in one hundred and eighty patients with essential hypertension.A Color Doppler Ultrasound system was used to investigate the intimal-medial thickness（IMT） of common carotid artery（CCA） and the plaque index of carotid artery.Results： ①The serum concentrations of CRP in the carotid atherosclerosis group were signicantly higher than those of CRP in the carotid artery normal group（P〈0.01）.②The serum concentrations of CRP in the carotid artery plaque group were signicantly higher than those of CRP in the normal carotid artery group（P〈 0.01）.③ The serum concentrations of CRP in the carotid artery plaque index class 2,3 groups were signicantly higher than those of CRP in noplaque group（P〈 0.01）.Conclusion： Serum C-reactive protein level is closely associated with carotid atherosclerosis in patients with essential hypertension.Inflammatory response may play an important role in the pathogenesis of carotid atherosclerosis with essential hypertension.

关 键 词：高血压 颈动脉粥样硬化 C-反应蛋白质 

分 类 号：R544.1[医药卫生—心血管疾病]