硝苯地平乳膏剂的制备与质量控制  

Preparation and quality control of Nifedipine cream

作　　者：李菲[1] 杨艳霞[2] 郭丰广[1] 郝吉福[1] 孔志峰[1] 宋涛[1] 

机构地区：[1]泰山医学院药学院,山东泰安271016 [2]泰山医学院,04级药学专升本山东泰安271016

出　　处：《泰山医学院学报》2007年第2期90-92,共3页Journal of Taishan Medical College

摘　　要：目的研制硝苯地平乳膏,并建立质量控制的方法。方法拟定三种不同处方与制备工艺,以基质的稳定性及外观性状为考察指标,采用综合评分法对基质处方和制备工艺进行筛选。制备硝苯地平乳膏,并考察其稳定性,用差示分光光度法测定含量。结果制备的硝苯地平乳膏外观性状良好,质量稳定,药物含量为84.29%,平均回收率100.69%。结论该乳膏剂处方合理,制备方法可行。Objective： To prepare Nifedipinecream and establish its standard of quality control Methods： The content of Nifedipine in preparation was determined by the UV spectrophotometric method and its stability tests were carried out. Results： The content of Nifedipine in preparation was 84. 29% and the recovery of the assay was 100. 69%. Conclusion： The formula was reasonable, and the preparation method was feasible.

关 键 词：硝苯地平 乳膏剂 制备 质量控制 

分 类 号：R944[医药卫生—药剂学]