肿瘤坏死因子-α基因多态性与慢性阻塞性肺疾病的关系  

Association between polymorphism in the gene coding for tumor necrosis factor-α and chronic obstructive pulmonary disease

作　　者：张颖[1] 王伟[1] 徐少华[1] 王晖[1] 

机构地区：[1]山东大学第二医院呼吸科,山东济南250033

出　　处：《泰山医学院学报》2007年第2期106-109,共4页Journal of Taishan Medical College

摘　　要：目的明确肿瘤坏死因子-α(TNF-α)基因多态性与中国汉族人吸烟者慢性阻塞性肺疾病(COPD)的关系。方法对COPD进行分子流行病学初步研究,采用病例对照研究设计,用聚合酶链反应-限制性片断长度多态性(PCR-RFLP)分析的方法年COPD患者和健康对照者TNF-α-308位基因多态性,计算比值比(OR)和95%可信区间(CI)。结果经调整年龄、性别及吸烟指数,COPD组和对照组TNF-α基因多态性没有明显差异(P>0.05)。结论TNF-α基因多态性是中国汉族人吸烟者COPD的危险因素。Objective： To investigate the Association between polymorphism in the gene coding for tumor necrosis factor -α（TNF- α）and chronic obstructive pulmonary disease（COPD） of smokers in Chinese Han nationality. Methods： this was a pilot study of the molecular epidemiology in patients with COPD. The research design was a case - control study. Polymerase Chain reaction （PCR） and restriction fragment length polymorphism （RFLP） were performed to genotype TNF -α -308 polymorphism I COPD patients and age and sex matched healthy controls. Calculate the odds ratio （OR） and the 95% confidence interval （CI）. Result： There was no significant difference in TNF- 17α polymorphism adjusted by age, sex and smoke index between COPD patients and controls. Conclusion： TNF - α polymorphism was a risk factor to COPD of smokers in Chinese Han

关 键 词：慢性阻塞性肺病 肿瘤坏死因子-Α 基因多态性 吸烟 遗传 

分 类 号：R563.9[医药卫生—呼吸系统]