阿立哌唑合并氯氮平治疗难治性精神分裂症  

A study of aripiprazole combined with clozapine in refractory schizophrenia

作　　者：马奇[1] 连和谈[1] 李丽霞[1] 

机构地区：[1]福建省泉州市第三医院,福建泉州362000

出　　处：《中国民康医学》2007年第23期1046-1046,1048,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:了解阿立哌唑(商品名:博思清)与氯氮平合并治疗难治性精神分裂症的治疗效果与不良反应。方法:对84例慢性难治性精神分裂症患者随机分为联合组和单一用药组,在治疗前、治疗后1、2、3月进行简明精神病评定量表(BPRS)评定。结果:总疗效联合组明显高于单一用药组。BPRS总分在治疗后2月即有明显下降,联合组不良反应较轻。结论:阿立哌唑合并氯氮平治疗慢性难治性精神分裂症有较好疗效,不良反应轻而少。Objective：To explore the efficacy and safety of aripiprazole and clozapine combination for the treatment of refractory schizophrenia. Methods：84 cases of chronic refractory schizophrenia were randomly assigned to two groups （ aripirazole with clozap- ine or clozapine alone） for 3. months and were assessed with the brief psychiatric rating scale （BPRS）. Results： aripiprazole combined with clozapine was superior to clozapine alone, mored efficacy and less side effects. Conclusions：

关 键 词：难治性精神分裂症 阿立哌唑 氯氮平 

分 类 号：R971.4[医药卫生—药品] R749.3[医药卫生—药学]