脑络通与绞股蓝总皂甙对动脉粥样硬化性疾病的疗效比较  

Comparison of Curative Effects between Naoluotong and Gypenosides on Atherosclerotic Disease

作　　者：陈文垲[1] 周仲瑛[1] 仲肇舒[2] 程学萱[2] 司晓晨[1] 顾锡镇[1] 吴敏[1] 高万龙 孙宗娟[2] 

机构地区：[1]南京中医药大学,南京210029 [2]江苏省老年医院

出　　处：《中国动脉硬化杂志》1997年第2期138-142,共5页Chinese Journal of Arteriosclerosis

基　　金：国家"八五"攻关课题

摘　　要：脑络通是用来治疗动脉粥样硬化性疾病的中药复方制剂，具有滋肾养肝、消痰祛瘀作用。为明确其治疗效果，周脑络通与绞股蓝总甙对103例动脉粥样硬化性疾病患者进行两盲临床对比观察，时间5个月以上。采用美国ATL公司彩色超声多谱勒血流声象系统在用药前后探测患者两侧颈动脉粥样硬化斑块及内中膜厚度，检测患者血脂、超氧化物歧化酶、脂过氧化物和血液流变学指标，部分病人检测血小板聚集率和心功能，并检测患者的血、尿常规和肝、肾功能，观察患者临床症状。结果发现脑络通组57块颈动脉粥样硬化斑块中15．8％（9／57）的斑块消除，47．4％（27／57）的斑块减轻，29．8％（17/57）的斑块不发展，总有效率为93％（53／57）；绞股蓝组分别为0％，2．8％（1／36）和47．2％（17／36），总有效率为50％（18／36）．脑络通组对斑块的消除、减轻、总有效率及斑块载面积减少方面皆明显优于绞股蓝组（P＜0．01或0．05）。脑络通可使增厚的内中膜减薄。在降低血总胆固醇、甘油三酯、低密度脂蛋白、升高血超氧化物歧化酶活性，降低脂过氧化物，降低全血低切粘度、纤维蛋白原、红细胞压积、血小板最大聚集率等方面皆优于绞股蓝组。提示脑络通在调血脂、抗氧化、抗血栓和改善血液流变学等方面均有作用．在临床症状和?Aim Naoluotong (NLT) is a compound Chinesepreparation that to be used in the treatment ofatherosclerosis. In this study, the effect of Naoluo-tong is compared with that of the Gypenosides in clini-cal practice.Methods Thorgh double-blind clinical observation,the patients were divided into Naoluotong group andGypenoside group. A color ultrasonic Doppler blood-now acoustic image system(ultramark-9) was used todetect the atherosclerosis plaque in the bilateralcarotid, measure the cervrical artery intima-media tu-nica thickness(CAIMT) and determine blood lipid, su-peroxide dismutase (SOD), lipid peroxide (LPO) andindexes of blood rheology. Part of the patients also hadtheir blood platelet aggregation rate (PAR) and heartfunction examined- Blood and urine routine and liverand kidney function examinations were conducted so asto find out about the safety of the medicine.Results Among the 57 patients with atherosclerosisplaques in the Naoluotong group, disappearance of theplaques occurred in 15. 8% (9/57), reduced plaquesoccurred in 47. 4K (27/57) and unchanged plaques oc-curred in 29. 8K (17/57) of the patients, the total effective rate being 93K (53/57). The total effective rateobtained in the Naoluotong group in resolving plaqueand reducing the cross section area was much higherthan that in the Gypenoside group (P<0. 01 or 0. 05).It was found that Naoluotong could reduce the thick-ness of the thickened tunica intima-media and had bet-ter effect than Gypenosides in reducing total choles-terol (TC ), triglycerides (TG ) and low densitylipoprotein cholesterol (LDLC) ; raising SOD and re-ducing LPO; and in reducing whole blood viscosity,fibringoen, packed cell volume, blood platelet maxi-mum aggregation rate, etc.Conclusion Naoluotong has better therapeutic effect than the total glycoside in Gypenoside treatingatherosclerosis, in that it can prevent the disease fromprogressing further and may even resolve the plaquesformedas a result of atherosclerosis.

关 键 词：动脉弱样硬化 脑络通 绞股蓝总皂甙 药物疗法 

分 类 号：R543.505[医药卫生—心血管疾病]