复方甘草酸苷联合还原型谷胱甘肽治疗酒精性肝硬化的疗效观察  

Clinical Efficacy of Compound Glycyrrhizin Combined with Reduced Glutathione on Patients with Alcoholic Liver Cirrhosis

作　　者：彭于仑[1] 

机构地区：[1]广西钦州市第二人民医院消化科,钦州市535000

出　　处：《中国药房》2007年第35期2772-2774,共3页China Pharmacy

摘　　要：目的:观察复方甘草酸苷对酒精性肝硬化的治疗效果。方法:40例酒精性肝硬化患者随机分为治疗组与对照组,前者给予复方甘草酸苷80mL+还原型谷胱甘肽1.20g静脉滴注,后者仅给予还原型谷胱甘肽1.20g静脉滴注,疗程均为2wk。结果:治疗组与对照组总有效率分别为90%、40%(P<0.01),治疗组治疗后的肝功能、肝纤维化指标均明显降低,与对照组比较差异非常显著(P<0.01)。结论:复方甘草酸苷联合还原型谷胱甘肽治疗酒精性肝硬化,可显著改善肝功能,抑制肝纤维化。OBJECTIVE： To observe the curative effects of compound glycyrrhizin used in combination with reduced glutahione for the treatment of alcoholic liver cirrhosis（ALC） .METHODS：40 patients with ALC were randomized into the treatment group and control group.The treatment group was treated with compound glycyrrhizin 80mL and reduced glutathione 1.20g to observe the changes in hepatic function, hepatic fibrosis, clinical symptoms and therapeutic effects;whereas the control group was treated only with reduced glutathione 1.20g.The course of treatment lasted 2 weeks for both groups.RESULTS： After treatment for 2 weeks, the serum glutamic pyruvic transaminase（ALT）, aspartate aminotransferase （AST）, γ- glutamyl transpeptidase（γ-GT）, total biliribin（TB）, hyaluronic acid（HA）, type Ⅲ procollagen（PC Ⅲ） and type Ⅳ collagen（Ⅳ- C） levels in the treatment group decreased markedly, the clinical symptoms were improved obviously, the total effective rates in the treatment group were 90% and there were significant differences in ALT, AST, γ- GT, TB, HA,PC Ⅲ, Ⅳ -C levels.Clinical symptoms and total effective rates between treatment group and control group showed significant difference（P 〈 0.01）. CONCLUSION： Compound glycyrrhizin combined with reduced glutathione can distinctly improve the hepatic functions and inhibit liver fibrosis of patients with alcoholic liver cirrhosis.

关 键 词：复方甘草酸苷 还原型谷胱甘肽 酒精性肝硬化 疗效 

分 类 号：R975.5[医药卫生—药品]