辅助孵化对高龄妇女IVF-ET临床结局的影响  

Assisted hatching on in vitro fertilization-embryo transfer in women with advanced age

作　　者：张琪瑶[1] 管群[1] 孔风云[1] 菅福琴[1] 任兰青[1] 王美玲[1] 

机构地区：[1]山东中医药大学第二附属医院生殖医学中心,济南250001

出　　处：《山东大学学报（医学版）》2007年第11期1156-1158,1167,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨辅助孵化对高龄妇女体外受精-胚胎移植临床结局的影响。方法回顾性分析96例高龄妇女体外受精-胚胎移植周期,其中行激光辅助孵化后移植52周期(AH组),常规胚胎移植44周期(常规组),比较两组患者临床妊娠率和胚胎种植率。结果AH组的临床妊娠率为28.85%(15/52),胚胎种植率为18.10%(19/105);常规组的临床妊娠率为20.45%(9/44),胚胎种植率为8.93%(10/112)。当基础卵泡刺激素(FSH)≥10(IU/L)或透明带厚度≥18μm时,AH组胚胎种植率明显高于常规组(P<0.05)。结论对于高龄妇女,尤其对于合并基础FSH≥10(IU/L)或移植胚胎透明带厚度≥18μm的患者在胚胎移植前行辅助孵化有助于提高胚胎种植率。Objective To study the effect of assisted hatching on in vitro fertilization-embryo transfer （IVF-ET） in women with advanced age. Method A retrospective analysis of 96 IVF-ET cycles was used to compare embryo transfer after laser-AH （ n = 52） and traditional CT-ET（ n = 44）. Results 18.10% （ n = 19） of the 105 embryos exposed to AH were implanted, and 8.93% （n = 10） of the 112 embryos not exposed to AH were implanted （P 〈0.05, （2 test）. There were no differences in the rate of clinical pregnancy between the two groups （28.85 % VS 20.45 %, P 〉 0.05）. When basal FSH≥10（IU/L） or embryos for transfer with zona thickness ≥ 18 μm, laser-assisted hatching increased the implantation rate （ P 〈 0.05, （2 test）. Conclusion Assisted hatching increases the implantation rate of IVF-ET in women with advanced age, especially in those with the basal FSH≥ 10（IU/L）or embryos for transfer with zona thickness ≥ 18 μm

关 键 词：生殖技术 激光 年龄因素 妊娠率 

分 类 号：R321.3[医药卫生—人体解剖和组织胚胎学]