成人持续性变应性鼻炎生活质量评价和相关性分析  

Analysis of quality of life of adult persistent allergic rhinitis

作　　者：王向东[1] 张罗[1] 赵岩[1] 刘承耀[2] 刘仲燕[3] 韩德民[1] 

机构地区：[1]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京100730 [2]首都医科大学,2007级博士研究生北京100069 [3]北京市耳鼻咽喉科研究所,北京100005

出　　处：《中国耳鼻咽喉头颈外科》2007年第11期667-669,共3页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金："十一五"国家科技支撑计划资助项目(2007BAI18B15);北京市科委科技计划项目(Z0005190041531);北京市科技新星计划(2006A67);耳鼻咽喉头颈科学教育部重点实验室(首都医科大学)

摘　　要：目的评价成人持续性变应性鼻炎(allergic rhinitis,AR)患者的鼻炎相关生活质量以及不同评价指标间的相关性。方法2006年4～9月北京地区持续性AR患者37例,男21例,女16例,年龄19～53岁,平均(31.86±8.27)岁;同期非AR对照组22例,男10例,女12例,年龄18～56岁,平均(35.59±11.72)岁。通过病史、典型症状和皮肤点刺试验确诊。患者对屋尘螨、粉尘螨、真菌和蟑螂等室内变应原以及树1、树2、豚草、藜和艾蒿等室外变应原敏感。使用鼻炎相关生活质量问卷(rhinoconjunctivitis quality of life questionnaire,RQLQ)评估生活质量。结果AR患者RQLQ的各项评分的平均分都明显超过对照组(P<0.001)。相关性分析显示:①夜间睡眠质量欠佳和鼻堵症状评分显著相关(r=0.537,P<0.01);②睡眠总分和鼻堵症状评分、鼻部症状总分显著相关(r=0.667,P<0.001;r=0.425,P<0.01);③睡眠总分和非鼻-结膜炎症状总分显著相关(r=0.434,P<0.01);④夜间睡眠欠佳和注意力难以集中显著相关(r=0.359,P<0.05);⑤非鼻-结膜炎症状总分和鼻部症状总分显著相关(r=0.434,P<0.01);⑥喷嚏症状评分和情感反应项目中的症状令人难堪项的评分显著相关(r=0.349,P<0.05)。结论持续性AR患者的鼻炎相关生活质量较非AR对照组受到明显影响。相关性分析提示鼻部症状可能是影响睡眠质量的主要原因,睡眠质量可能影响非鼻-结膜炎症状,喷嚏可能是导致患者感觉症状令人难堪的主要原因。OBJECTIVE To evaluate the quality of life in adult with persistent allergic rhinitis and the correlation of the items. METHODS Thirty-seven adult patients with persistent allergic rhinitis and 22 non-allergic rhinitis control subjects participated this study. Rhinoconjunctivitis quality of life questionnaire （RQLQ） was used to assess the quality of life of the subjects. RESULTS The mean scores of the 7 domains items of patients were significantly higher than those of control subjects. The score of lack of a good night＇s sleep was significantly correlated with the score of stuffy nose（r =0.537, P〈0.01）. The total score of sleep items was significantly correlated with the score of stuffy nose and the total score of nasal symptoms respectively （r =0.667, P〈0.001; r =0.425, P〈0.01）, The total score of sleep items was significantly correlated with the score of total score of Non-hay-fever symptoms（r =0.434, P〈0.01）. The score of lack of a good night＇s sleep was significantly correlated with the score of poor concentration （r =0.359, P〈0.05）, The total score of non-hay-fever symptoms was significantly correlated with the total score of nasal symptoms （r =0.434, P〈0.01 ）, The score of sneezing was significantly correlated with the score of embarrassed by nose/eye symptoms （r =0.349, P〈0.05）. CONCLUSION The quality of life of the patients with persistent allergic rhinitis was significantly affected. The nasal symptoms may be the main factor affecting the quality of sleep. The quality of sleep may affect non-hay-fever symptoms. Sneezing may be the main cause of embarrassment.

关 键 词：鼻炎 变应性 常年性 生活质量 问卷调查 

分 类 号：R765[医药卫生—耳鼻咽喉科]