高血压患者血管内皮功能及颈动脉内-中膜厚度与冠心病事件关系的研究  

Correlation of Endothelial Function and Carotid Intima-media Thickness to Cardiovascular Events in Hypertension Patients

作　　者：孙妍[1] 王国干[1] 关键[1] 沈磊 谢后蓉 朱俊[1] 

机构地区：[1]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院心内科急诊抢救中心,北京市100037 [2]煤炭总医院功能科

出　　处：《中国超声医学杂志》2007年第12期908-910,共3页Chinese Journal of Ultrasound in Medicine

摘　　要：目的研究高血压患者肱动脉血流介导血管舒张(FMD)及颈动脉内-中膜厚度(IMT)与冠心病事件的相关性。方法对72例高血压患者(按有、无冠心病事件分为两组)和21例正常人应用高分辨率超声测量并计算肱动脉FMD,硝酸甘油介导的血管舒张(NID)及颈动脉IMT。结果(1)同正常人(8.85±5.08)%比较,无冠心病事件组和有冠心病事件组的FMD[(4.00±3.93)%;(2.53±2.92)%]显著降低(P<0.05)。而三组NID差异无统计学意义(P>0.05);(2)同正常人(0.74±0.24)mm比较,无冠心病事件组和有冠心病事件组的IMT[(1.08±0.25)mm;(1.33±0.23)mm]明显增厚(P<0.01)。结论原发性高血压患者同正常人比较无论是否存在冠心病事件内皮细胞功能均受损且IMT增厚,高血压伴有冠心病事件者较无事件者内皮细胞功能明显受损,IMT增厚。Objective To investigate whether endothelium dependent vasodilation （flow-mediated dilatation FMD） was associated with cardiovascular events in a group of hypertension patients. Methods Totally 72 patients with hypertension were recruited and divided into two gloups ： group 1, without cardiac events, gloup 2, with cardiac events. Twenty-one normal subjects served as the control. Results 1） Compared the control to the group 1 and 2, the FMD was 8.85±5.08% vs 4.00±3.93%, 2.53±2.92%, respectively, all P〈0.01. NID had no significant difference between all the groups P〉0. 05. 2） There were significant differences in IMT between the control and group 1 and 2 （all P〈 （0.01）. Conclusions FMD was impaired in hypertension patients with or without cardiovascular events. In hypertension patients with cardiovascular events, IMTs were increased gradually.

关 键 词：内皮功能异常 高血压 冠心病事件 

分 类 号：R544.1[医药卫生—心血管疾病]