尿酸与胰岛素抵抗关系的人群研究  

Correlation between serum uric acid and insulin resistance

作　　者：王淼[1] 赵冬[1] 李光伟[2] 王薇[1] 刘静[1] 刘军[1] 刘飒[1] 秦兰萍[1] 周广华[3] 

机构地区：[1]首都医科大学附属北京安贞医院 北京市心肺血管疾病研究所,100029 [2]卫生部中日友好医院内分泌科 [3]北京大学校医院

出　　处：《中华医学杂志》2007年第46期3260-3263,共4页National Medical Journal of China

基　　金：北京心血管病高技术实验室资助项目(953850700);北京市科技新星计划课题资助项目(2003B26)

摘　　要：目的研究血清尿酸与胰岛素抵抗的关系。方法利用1999年在北京市自然人群中通过分层随机抽样获得的数据,以胰岛素敏感指数(IAI)作为评价胰岛素敏感性的指标,在年龄为35～64岁的1056人中分析了血清尿酸与胰岛素敏感指数及胰岛素抵抗的关系。结果(1)IAI 的中位数水平随血清尿酸水平的升高而降低,血清尿酸水平最高组中 IAI 的中位数为0.027,比最低组低32.5%。(2)胰岛素抵抗的患病率随血清尿酸水平的升高而增加(x^2=17.475,P<0.001),血清尿酸水平最高组中胰岛素抵抗患病率为33.9%,是最低组的2.46倍。(3)采用多因素 Logistic 回归分析调整了性别、年龄和代谢综合征的主要成分后,血清尿酸和胰岛素抵抗的关联仍存在(OR=1.201,P=0.004)。结论血清尿酸与胰岛素抵抗存在关联,并独立于性别、年龄和代谢综合征中的主要成分。应重视尿酸代谢异常在代谢综合征发生及发展中的作用。Objective To assess the correlation between serum uric acid and insulin resistance in natural population of Beijing. Methods 1056 people without-diabetes, 460 males and 596 females, aged 35-64 was selected from the natural population in Beijing using stratified-random sampling method. Serum uric acid, fasting blood glucose, insulin and other metabolic parameters were measured. The insulin activity index（IAI） was calculated to assess insulin resistance. Results The natural logarithm of IAI was decreased with the elevation of serum uric acid level （ F = 47. 884, P 〈 0. 001 ）. The prevalence of insulin resistance increased with the elevation of uric acid level, from 13.8% in quartile 1 to 33.9% in quartile 4. Compared to the quartile 1, the odds ratio（OR） of the quartile 2 for prevalence of insulin resistance was 1. 935 ; the OR of the quartile 3 was 1.590 ; the OR of the quartile 4 was 2.088. Uric acid was independently correlated with insulin resistance after adjustment for sex, age and main components of metabolic syndrome （MS）. Conclusion Serum uric acid is correlated with insulin resistance in Beijing natural population after adjustment of sex, age, and the main components of MS.

关 键 词：尿酸 胰岛素抗体 代谢综合征 

分 类 号：R587.2[医药卫生—内分泌]