260例TCT正常的宫颈糜烂患者HPV感染状况分析  

Investigation of HPV Infection in 260 Cervical Erosion Patients with Normal TCT

作　　者：曲秀平[1] 夏蓓[1] 杨宁[1] 

机构地区：[1]首都医科大学宣武医院,北京100053

出　　处：《实用妇产科杂志》2007年第10期618-620,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:探讨超薄液基细胞学检测(TCT)结果正常的宫颈糜烂患者人乳头瘤病毒(humanpapilloma virus,HPV)的感染状况。方法:选择TCT检查结果为正常的宫颈糜烂患者260例,采用HybriMax方法进行HPV基因型分型检测,分析该人群中HPV的感染率及病毒亚型的分布状况。结果:受检患者中HPV感染者86例(感染率为33.08%),感染者平均年龄30.76±5.79岁,以单一病毒亚型感染为主。重度比轻度感染率高(P<0.05),乳突型感染率显著高于单纯型及颗粒型(P<0.01)。在单一病毒亚型感染者中,感染率最高的为58亚型。多重感染中,最高者为16亚型。结论:TCT正常的宫颈糜烂患者中,依然有较高的HPV感染,对宫颈糜烂患者实施HPV检测与追踪,将有利于对宫颈癌高危人群的监控。Objective： To investigate the infection of human papilloma virus （HPV） in cervical erosion patients with normal TCT （thin prep liquid - based cytology test）. Methods. HPV was detected by HybdMax. The infection rate and virus genotype were analyzed. Resuits.Among the 260 patients, 86 cases were infected with HPV （33.08%）, most of which with single HPV infection. The mean age of HPV infection was 30.76 ± 5.79 years. The HPV infection rate was higher in severe erosion patients than the light cases （ P 〈 0,05）, and also higher in nipple type and granular type than the simple type of cases （ P〈0.01）. HPV58 was the major genotype among the single HPV infection, and HPV16 was major genotype in patients with multiple HPV infection.Conclusions.The infection rate is high in cervical erosion patients with normal TCT. Detecting and tracing HPV infection in cervical erosion cases may help to monitor the population with high risk of cervical carcinoma.

关 键 词：宫颈糜烂 超薄液基细胞学检查 人乳头瘤病毒 

分 类 号：R711.32[医药卫生—妇产科学]