氟罗沙星单剂和多剂治疗急性尿路感染的比较  

Single dose vs multiple doses of fleroxacin in therapy of acute urinary tract infections

作　　者：焦红梅[1] 张婴元[1] 吴培澄[1] 吴卫红[1] 汪复[1] 

机构地区：[1]上海医科大学附属华山医院抗生素研究所

出　　处：《新药与临床》1997年第4期209-211,共3页

摘　　要：目的：观察氟罗沙星治疗单纯性下尿路感染的疗效及安全性，并对单剂和多剂２种治疗方案进行比较。方法：单剂组（女性，３０例；年龄４１±ｓ１４ａ）用氟罗沙星片４００ｍｇ顿服；多剂组（男性２例，女性２８例；年龄４７±１５ａ）用氟罗沙星片２００ｍｇ，ｐｏ，ｑｄ，共７ｄ。结果：２组有效率均为９７％，痊愈率和细菌清除率分别为９３％和９７％，不良反应的发生率分别为１０％和０。结论：氟罗沙星治疗单纯性下尿路感染疗效良好，不良反应轻微，２种给药方案有效性和安全性相仿（Ｐ＞０．０５）。AIM: To compare the efficacies and safety between the single-dose and multiple-dose regimens of fleroxacin. METHODS: Sixty paients with uncomplicated urinary tract infections were randomly divided into 2 groups: Single-dose group of 30 patients (F 30; age 41±s 14 a) received fleroxacin 400 mg, po. Multiple-dose group of 30 patients (M 2, F 28; age 47±15 a) received fleroxacin 200 mg, po, qd for 7 d. RESULTS: Both effective rates were 97%, bacterial eradication rates were 93% and 97%, respectively. The adverse reaction rate was 10% in the former group and 0 in the latter. CONCLUSION: Fleroxacin is a safe and effective drug for the treatment of urinary tract infections and its single and multiple-dose regimens are similar.

关 键 词：氟罗沙星 尿路感染 药物疗法 

分 类 号：R691.305[医药卫生—泌尿科学] R696.05[医药卫生—外科学]