骨松Ⅱ号治疗绝经后骨质疏松症临床生化指标观察  

Clinical Biochemical Observations on Treatment for Postmenopausal Osteoporosis with Gusong-Ⅱ

作　　者：史炜镔[1] 张昊 杜宁[1] 王济纬[1] 符诗聪[1] 杨建[1] 曲克服[1] 李国衡[1] 

机构地区：[1]上海第二医科大学附属瑞金医院,浙江省丽水市人民医院,上海市伤骨科研究所

出　　处：《中国中西医结合杂志》1997年第7期398-400,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的：评估骨松Ⅱ号治疗绝经后骨质疏松症的疗效，并试图揭示其机理。方法：以３５例年龄４９～６２岁、绝经时间５．６年的绝经后骨质疏松症妇女为治疗对象，于治疗后６～９个月、１～２年分期随访。疗程６个月～２年１个月不等，平均疗程为１年２个月。治疗前后作血雌二醇（Ｅ２）、睾酮（Ｔ）、晨尿Ｃａ／Ｃｒ、２４ｈ尿Ｃａ／Ｃｒ、２４ｈ尿Ｅ２、２４ｈ尿羟脯氨酸（ＨＯＰ）等生化指标的测定。结果：治疗６～９个月及治疗１～２年后，血及２４ｈ尿Ｅ２显著升高，治疗１～２年后血Ｔ与尿Ｃａ／Ｃｒ显著下降。血Ｅ２、２４ｈ尿Ｅ２分别与晨尿Ｃａ／Ｃｒ、血Ｔ、２４ｈ尿Ｃａ／Ｃｒ、２４ｈ尿ＨＯＰ治疗前后变化值呈显著相关。结论：骨松Ⅱ号具有提高绝经后妇女血Ｅ２水平、降低尿Ｃａ／Ｃｒ及２４ｈ尿ＨＯＰ、抑制骨吸收的作用；其升高血Ｅ２水平的作用，可能与促进Ｔ向Ｅ２的转化有关。Objective:To evaluate the curative effect of Cusong Ⅱ for postmenopausal osteoporsis,and try to reveal its mechanism. Methods: Thirty-five women, 49 to 62 years old, with 5.6 years menopause were treated as the subjects and followed for 6～9 months, 1～2 years.The course of treatment ranged from 6 months to 2 years and 1 month, and the average treatment pened was 1 year and 2 months. Some related biochemical markers, such as serum estradiol (E2), testosterone (T), lasting morning urinary Ca/Cr, 24h urinary Ca/Cr,24h urinary E2, 24h urinary hydroxyproline (HOP), were measured before and after treatment. Results: After 6～9 months or 1～2 years, the levels of serum E2 and 24h urinary E2 were raised significantly, while the levels of serum T and urinary Ca/Cr reduced evidently after 1- or 2- year treatment. The levels of serum E2 and 24h urinary E2 were significantly correlated with levels of lasting morning urinary and 24h urinary Ca/Cr, serum T, 24h urinary HOP respectively.Conclusion: Gusong-Ⅱ could elevate the serum E2 levels of postmenopausal women, reduce the discharge of urinary Ca/Cr and HOP, inhibit the bone resorption. The rose of the serum E2 level might be correlated with the converison of T into E2.

关 键 词：骨松Ⅱ号 绝经后 骨质疏松症 中医药疗法 

分 类 号：R274.911[医药卫生—中西医结合]