肠炎宁糖浆能影响内脏高敏感大鼠结肠电及运动  

The Effect of Changyanning Syrup about Colonic Electrophysiology and Motility of Visceral Hypersensitivity Rat

作　　者：印媛君[1] 吕宾[2] 杨午鸣[1] 柯庆[1] 丁瑞峰[2] 

机构地区：[1]浙江中医药大学基础医学院,杭州310053 [2]浙江中医药大学附属第一医院

出　　处：《浙江中医药大学学报》2007年第4期417-419,共3页Journal of Zhejiang Chinese Medical University

基　　金：浙江省横向资助项目(No:2002-C21)~~

摘　　要：[目的]探讨肠炎宁糖浆对内脏高敏感大鼠结肠电活动和结肠运动的影响。[方法]实验分对照组、模型组和肠炎宁糖浆组,后两组腹腔注射鸡卵清蛋白使大鼠内脏致敏。两周后,对照组0.7ml生理盐水灌胃、模型组0.7ml生理盐水灌胃、肠炎宁组0.7ml肠炎宁糖浆灌胃。持续灌胃1月后,记录结肠快波、慢波及收缩波,观察消化间期复合肌电IMC的周期,Ⅲ期持续时间,快波和慢波的波动率、平均最大振幅。结肠收缩波数目、收缩波指数。[结果]模型组消化间期复合肌电IMC的周期延长,Ⅲ期持续时间延长,快波的波动率加快,平均最大振幅增大(P<0.01)。慢波的波动率加快。收缩波数目增加,收缩波指数增大。经肠炎宁糖浆治疗后消化间期复合肌电IMC的周期缩短,Ⅲ期持续时间缩短(P<0.05),最大振幅减小,其余无差异。[结论]内脏高敏感大鼠结肠电及运动有明显异常。肠炎宁糖浆治疗内脏高敏感可能的机制是恢复部分被改变的结肠电,达到治疗效果。[Objective] Probing into the effect of Changyanning syrup about colonic electrophysiology and motility of visceral hypersensitivity rat. [Methods] The test consists of the model series and the control series and the Changyanning syrup series,and the two latter rats were sensitized by intraperitoneal injection of chicken egg albumen. After two weeks, the stomach is poured 0.7ml＇s normal saline by blank space series, 0.7ml＇s normal saline by model series, 0. 7ml＇s Changyanning syrup by Changyanning series. Continue to pour stomach in a month,writing colon fast wave, slow wave and the colon contraction,the observation of interdigestive myoelectric complex IMC cycle, Ⅲ times duration, fast wave and slow wave propagation rate, the largesttest amplitude, the amount of the colon contraction, the index of the colon contraction. [Result] The model series＇ interdigestive myoelectric complex IMC cycle prolongs, Ⅲ times duration prolongs, fast wave and slow wave propagation rate speeds up,the largesttest amplitude broadens. The slow wave propagation rate speeds up. The amount of the colon contraction speeds up, the index of the colon contraction speeds up. After Changyanning series treated,interdigestive myoeleetrie complex IMC cycle cuts down, HI times the duration cuts down, the largesttest amplitude decreases. [Conclusion] There are quite differencs between model group and control group in electricity and motion of visceral hypersensitivity rat. Changyanning syrup treating visceral hypersensitivity is by means of partly recovering the colon fast and slow wave and contraction wave rhythm and amplitude.

关 键 词：内脏高敏感 肠炎宁糖浆 快波 慢波 振幅指数 

分 类 号：R285.5[医药卫生—中药学]