还原型谷胱甘肽治疗中重度新生儿缺氧缺血性脑病肾功能损害  

Therapeutic Effect of Reduced Glutathione on Medium and Serious Hypoxic-ischemic Encephalopathy Accompanied by Kidney Damage.

作　　者：汤晓蓉[1] 徐春莺[1] 翟长华[1] 薛育政[2] 

机构地区：[1]江苏省大丰市人民医院儿科,江苏大丰224100 [2]无锡市第三人民医院消化科

出　　处：《药物流行病学杂志》2007年第6期328-330,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:探讨还原型谷胱甘肽对中重度新生儿缺氧缺血性脑病(HIE)肾功能损害的治疗效应。方法:将中重度HIE伴肾功能损害的患儿70例。随机分为治疗Ⅰ组和Ⅱ组。治疗Ⅰ组加用还原型谷胱甘肽150 mg·kg^(-1)·d^(-1),溶于15～20 ml注射用水中,ivd,其余治疗两组相同。于治疗前和治疗1周后检测血清BUN、Cr、β_2-MG值及尿β_2-MG值,观察临床病情变化。结果:两组BUN、Cr、β_2-MG值及尿β_2-MG值均较治疗前明显好转(P<0.05);治疗Ⅰ组BUN、Cr及β_2-MG值较治疗Ⅱ组明显好转(P<0.05);治疗Ⅰ组有效率较治疗Ⅱ组高(P<0.05)。结论:还原型谷胱甘肽对中重度HIE伴肾功能损害具有较好的治疗效应。Objective： To investigate the therapeutic effects of reduced glutathione on medium and serious hypoxic-ischemic encephalopathy. Method： 70 neonates with medium and serious hypoxic-ischemic encephalopathy were divided into two groups： group Ⅰ and group Ⅱ, GSH treated groups were given GSH at a dosage of 150 mg/（kg·d） body weight. The following parameters were measured： blood urea nitrogen（ BUN ）, serum creatinine（Cr） , serum β2- microglobulin（β2- microglobulin） and urineβ2- microglobulin before and after the treatment. The patients＇conditions were observed at the same time. Result： The value of BUN, Cr, serum and urineβ2- microglobulin in the two groups improved more obviously than before treatment（ P 〈 0.05 ）. The improvement rate of BUN, Cr and serumβ2- microglobulin in group Ⅰ was higher than that of group Ⅱ （P 〈 0.05 ）. Conelusion： GSH had its therapeutic effect on medium and serious hypoxic-ischemic encephalopathy accompanied by kidney damage.

关 键 词：谷胱甘彬还原型 新生儿脑病 缺氧缺血性 肾损害 Β2-微球蛋白 

分 类 号：R722.1[医药卫生—儿科]