从影响类风湿关节炎关节软骨破坏相关血生化和免疫因素比较中西药治疗效果的特点  

Comparative Study on Characteristics of Chinese and Western Medicine for Treatment of Rheumatoid Arthritis Regarding Cartilage Erosion Related Blood Biochemical and Immunological Factors

作　　者：刘学文[1] 查青林[2] 何羿婷[3] 闫小萍[4] 苏励[5] 宋跃进[6] 曾升平[7] 刘维[8] 冯兴华[9] 钱先[10] 朱婉华 林色奇[2] 吕诚[1] 吕爱平[1] 

机构地区：[1]中国中医科学院临床基础医学研究所,北京100700 [2]江西中医学院 [3]广州中医药大学第二附属医院 [4]北京中日友好医院 [5]上海中医药大学附属龙华医院 [6]湖北省中医药研究院 [7]成都中医药大学附属医院 [8]天津中医学院第一附属医院 [9]中国中医科学院广安门医院 [10]江苏省中医院 [11]南通良春中医药临床研究所

出　　处：《中国中西医结合杂志》2007年第12期1090-1093,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家十五攻关计划(No.2001BA701A17);国家自然科学基金项目(No.3047212)

摘　　要：目的分析类风湿关节炎(RA)软骨破坏相关血生化和免疫因素,并探讨中西药对其影响的特点。方法397例确诊活动期RA病例随机分成中药治疗组203例和西药治疗组194例。西药治疗方案包括非甾体抗炎药和慢作用药,中药治疗包括基础治疗和辨证用药,6个月为1个疗程。治疗前后收集患者相关血生化和免疫检测指标,通过数理统计分析,从中确定软骨破坏相关因素,比较中西药对这些相关因素的影响。结果软骨破坏程度与红细胞(RBC)及血小板(PLT)计数密切相关;治疗前后比较,中药组RBC计数升高且有统计学意义,西药组PLT计数降低且有统计学意义;中药组升高RBC的幅度与西药组比较有统计学意义,而西药组降低PLT的幅度与中药组比较无统计学意义。结论中西药均能改善RA软骨破坏相关因素,但改善途径不同。Objective To analyse the cartilage erosion related blood biochemical and immune factors in rheumatoid arthritis （RA） and to explore the special influences of Chinese medicine （CM） and Western medicine （WM） on these factors. Methods Three hundred and ninety-seven patients, with confirmed diagnosis of active RA, were randomly assigned to the WM group （194 patients） and the CM group （203 patients）. The WM applied covered non-steroid anti-inflammatory agents and slow acting medicine; and the CM given included basic remedy and syndrome differentiating medication. Related blood biochemical and immunological indexes were de- termined before and after treatment to screen out the cartilage erosion related factors and to compare the influence of CM and WM on them. Results Patients＇ peripheral red blood cell （RBC） and platelet （PLT） count were changed closely along with their degree of cartilage erosion. RBC count increased in the CM group and PLT count lowered in the WM group after treatment, all showed statistical significance; comparison of the two indexes between the two groups showed that statistical difference presented in RBC but not in PLT count. Conclusion Both WM and CM can ameliorate the cartilage erosive factor in RA, but they are acting in different ways.

关 键 词：红细胞 血小板 软骨破坏 类风湿关节炎 中西药治疗 

分 类 号：R593.22[医药卫生—内科学]