系统性红斑狼疮与其他风湿病的血栓栓塞性疾病对比研究  

A Control Study of Thromboembolism Events betwween Systemic Lupus Erythematosus and Other Rheumatic Disease

作　　者：李凝[1] 陈波[2] 苏厚恒[1] 

机构地区：[1]山东省青岛市市立医院东部医院免疫风湿科,266000 [2]山东省青岛市市立医院东部医院放射科,266000

出　　处：《中国全科医学》2007年第23期2003-2004,共2页Chinese General Practice

摘　　要：目的探讨系统性红斑狼疮伴发血栓栓塞性疾病的危险因素,并与其他风湿病进行比较。方法回顾性分析2001～2006年在我院免疫风湿科住院的20例诊断明确的风湿病患者,分为系统性红斑狼疮(SLE)组10例,对照组10例,包括系统性血管炎患者6例,原发性干燥综合征患者3例,多发性肌炎患者1例。结果10例SLE患者发生了14次血栓栓塞形成事件,10例对照组患者发生了13次血栓栓塞形成事件。两组患者发生血栓栓塞事件时的年龄和急性反应蛋白间差别有显著性意义(P<0.05),血脂水平及病程间差别无显著性意义(P>0.05)。结论SLE患者易于过早发生动脉硬化,炎症本身是其重要的发病因素之一,应深入研究其发病机制,并进一步提出预防和治疗措施。Objective To investigate the diagnosis and therapy of rheumatic diseases patients with thromboembolism. Methods 20 inpatients with rheumatic diseases were divided into two groups, which included 10 patients with SLE, and 10 pa- tients with other rheumatic diseases, including 6 with systemic vasculitis, 3 with pSS, and 1 with PM. The cases were reviewed retrospectively in Qingdao Municipal Hospital during 2001 - 2006. Results There were 27 events that happened in the 20 pa- tients, including 14 in 10 SLE patients and 13 in the control group. The SLE patients were much younger than the control when they had the events （ P 〈0. 01）, and the level of the C -reactive protein （CRP） was higher than the control, too （ P 〈 0.05）, while there were no statistic significance in the level of the lipids and the course of the disease （ P 〉 0. 05）. Conclu- sion The SLE patients were liable to have artherosclerotic disease earlier, it should be studied further and the preservation and treatment should be proposed.

关 键 词：红斑狼疮 系统性 血栓栓塞 梗死 动脉硬化 

分 类 号：R593.2[医药卫生—内科学]