仿硒酶研究进展  

Progress in Selenoenzyme Mimics

作　　者：刘俊秋[1] 罗贵民[1] 沈家骢[1] 

机构地区：[1]吉林大学超分子结构与材料教育部重点实验室,长春130012

出　　处：《化学进展》2007年第12期1928-1938,共11页Progress in Chemistry

摘　　要：硒是人体中必需的微量元素,它与各种疾病和人类健康息息相关。硒在生物体内以硒代半胱氨酸形式表现其生理活性和功能。为了探索硒在硒蛋白中结构和功能关系并可能发展成硒相关的适用药物,人们付出许多努力来发展硒蛋白模拟化学。由于硒酶——谷胱甘肽过氧化物酶(GPX)重要的抗氧化作用以及潜在的药用价值,国际上广泛开展了对它的人工模拟研究。本文对近年来硒酶模拟化学和生物学相关研究进展进行了综述。Selenium, an essential trace element, has a long history of association with human health and diseases and exerts its important biological role as selenocysteine residue in selenoproteins. For the exploration of the structural and functional importance of selenium in selenoproteins and the potential applications in the development of selenium related medicine, significant efforts have been made in selenoprotein biomimetic chemistry. Because of the unique redox properties of selenium in mammalian selenoenzyme glutathione peroxidase （GPX）, a number of organoselenium/tellurium compounds and selenoproteins were developed to mimic the native GPX. Herein, several strategies containing chemical and biological techniques or the combination of both for the redesign of selenoenzyme structure and function have been reviewed.

关 键 词：硒酶 谷胱甘肽过氧化物酶 人工酶 硒 抗氧化 

分 类 号：Q814[生物学—生物工程]