弥散张量成像揭示部分及全面发作癫痫患者的丘脑改变  

Different Alterations in Thalamus between Partial Seizure and Secondary Generalized Seizure——A Diffusion Tensor Study on 3T MR

作　　者：吕粟[1] 唐鹤菡[1] 陈芹[2] 欧阳络[3] 陈华富[3] 周东[2] 邹翎[1] 黄晓琦[1] 张体江[1] 李东明[1] 龚启勇[1] 

机构地区：[1]四川大学华西医院放射科华西医学磁共振中心 [2]四川大学华西医院神经内科 [3]电子科技大学生命科学院

出　　处：《首都医科大学学报》2007年第6期713-716,共4页Journal of Capital Medical University

基　　金：高等学校博士学科点专项科研基金(20060610073);教育部留学回国人员科研启动基金(2005383-10-5);四川省青年科技基金会杰出青年科学基金(05ZQ026-031)资助项目~~

摘　　要：目的分析部分发作(PS)及部分继发全面发作癫痫患者(SGC)脑弥散张量的改变情况。方法本研究纳入11例PS患者,11例SGC患者及15例正常对照者。弥散张量成像采集采用3.0T磁共振仪,用15个方向的单次激发平面回波序列。采集数据用DTI-Studio软件计算每个受试者表观弥散系数图,然后用基于体素(VBA)的方法进行分析,取校正后P<0.05为有意义区域。基于VBA的发现,本研究对双侧丘脑的表现弥散系数图(ADC)值进行感兴趣区(ROI)分析,采用SPSS 11.5统计软件包进行统计分析,以P<0.05为差异有统计学意义。结果VBA结果显示PS和SGC患者均存在双侧上纵束、胼胝体及双侧颞叶等区域白质ADC值的增加。但双侧丘脑ADC值增加只有在SGC患者才能观察到。ROI分析结果同样显示SGC患者双侧丘脑ADC值的增加。结论本研究结果支持皮质丘脑环路假说,即丘脑功能的异常导致继发全面癫痫的发作。Objective The present study is aimed at characterizing the different diffusion alterations between patients with partial seizure（PS） and secondary generalized seizure（SGC）.Methods Eleven right handed patients with PS（mean age=18.1±3.6 years,4 males and 7 females） and 11 age,sex,handedness,epileptogenic area and disease duration matched patients with SGC（mean age=19.3±5.6,4 males and 7 females） were recruited.All patients had normal findings on conventional MRI and their diagnoses based on video,EEG telemetry and clinical manifestations. Fifteen right handed age and sex matched normal controls（mean age=18.5±5.5,5 males and 10 females） were also recruited.Diffusion tensor imaging（DTI） was acquired using a 3.0T MR scanner（GE EXCITE,Milwaukee,USA） by employing a spin echo single-shot EPI sequence with 15 directions（TR/TE=10 000/70.8 ms,slice thickness=3.0 mm,FOV=24 cm^2,matrix=128×128,b value=0,1 000 s/mm^2）.Apparent diffusion coefficient（ADC） and FA maps were generated from each participant＇s DTI scan using DTI-Studio software（http：//www.cmrm.med.jhmi.edu）.VBA was carried out using SPM2（http：//www.fil.ion.ucl.ac.uk/spm/software/）.Prior to the analysis,both ADC and FA maps were normalized using the parameters determined from the normalization of the b=0 image to MNI T2 template.All normalized maps were smoothed with a 6-mm FWHM isotropic Gaussian kernel.Statistical comparisons were performed using ANCOVA among PS,SGC and normal controls.A P value of less than 0.05 corrected after multiple comparisons was deemed to be significant.Based on VBA findings,the ROI analysis of bilateral thalami were performed among the three groups using two sample t test in SPSS 11.5 and a P value of less than 0.05 was deemed to be significant.Results VBA analysis showed significantly increased ADC in both PS and SGC groups including bilateral superiorlongitudinal fasciculus,corpus callosum and bilateral temporal stem areas（P corrected〈0.05）.Only patients with SGC showed significa

关 键 词：癫痫 磁共振 弥散 

分 类 号：R814.49[医药卫生—影像医学与核医学]